Study of the mechanism of cyclization and decomposition of methylketones oxindoles in acidic medium

الملخص EN

The stechiometry of the paratoluene sulphonic acid is a determining factor of the reaction of cyclization of the oxindolic methylketone 1.

Indeed, the oxindolic methylketone 1 is cyclized in pentacyclic compound 2 in the presence of an adequate quantity of paratoluene sulphonic acid in good yield.

Obtaining the tow epimeric indolenines 3a and 3b enabled us to explain the mechanism of this reaction.