Genetic polymorphisms of GSTM1 and GSTT1 genes and endometrial cancer in Basrah, South of Iraq

الملخص EN

T he genes glutathione S- transferase M1 (GSTM1) and GSTT1 involved in phase II metabolism catalyse glutathione – mediated reduction of exogenous and endogenous electrophiles.

A case control study was designed to identify the association between polymorphisms at GSTM1 and GSTT1 genes and endometrial cancer risk.

While there was a lack of association between GSTM1 null genotype with the risk of endometrial cancer, the null genotype of GSTT1 had a 5.7 fold increased risk toward endometrial cancer (OR=5.76; 95% CI = 2.07-15.97).

Both GSTM1, GSTT1 null genotype increased risk to about 3 fold.

When stratified according to different grades of endometrial cancer the GSTM1 was more representative in grade III (OR=2.6), the association becomes stronger when the GSTT1 gene was also null (OR= 4.6).