Synthesis of new schiff bases and 2, 3-disubstituted-1, 3-thiazolidin-4-one derivatives containing benzothiazole moiety

الملخص EN

Two series of Schiff Bases and 2,3-disubstituted-1,3-thiazolidin-4-one derivatives were synthesized .

Reaction of 2-mercaptobenzothiazole with α-chloro acetic acid gave compound[I].

Esterification of carboxylic moity of compound [I] , using absolute methanol in the presence of conc .

H2SO4 yielded acorresebonding ester [II] , wich was condensation with hydrazine hydrate to give acid hydrazide [III] .

The new Schiff bases [V]n were synthesized by reaction of acid hydrizide with dialdehyde [IV]n in the presence of glacial acetic acid .

The thiazolidinone derivatives [VI]n have been obtained from the azomethines through the addition of thioglycolic acid .

Their chemical structures have been confirmed by melting points , FTIR and 1HNMR (of some of them) .

Benzothiazole , thiazolidinone.