Salivary and plasma analysis of oxidative stress biomarkers in end stage renal failure patients

الملخص EN

Background : End Stage renal disease represents a clinical state or condition in which there has been an irreversible loss of endogenous renal function.

To evaluate role of oxidative stress & anti oxidant in chronic renal failure patients by measuring malondialdehyde & uric acid in their plasma and saliva in comparison with apparently healthy control group.

Materials &methods : The study was conducted on 60 Chronic renal failure patients at Al-Hussein teaching hospital , Karbala (Iraq) & 30 apparently healthy control group.

Laboratory measurements of salivary &plasma levels of oxidants ,antioxidants markers (MDA, uric acid) was done on hem dialysis patients compared to age & sex matched apparently healthy control group.

Results : Salivary & plasma (malondialdehyde, uric acid ) showed highly significant differences between chronic renal failure patients & apparently healthy control groups.

This study was the first study that measure salivary MDA in end stage renal failure patients.

Conclusion : Higher salivary, plasma oxidants & antioxidants concentrations of end stage renal failure patients with increase salivary components disturbances in comparison with apparently healthy control group.