Immunohistochemical expression of actin and s100 in pleomorphic adenoma and mucoepidermoid carcinoma
المؤلفون المشاركون
Majid, Ahlam H.
Rashid, Farah S.
المصدر
Journal of Baghdad College of Dentistry
العدد
المجلد 23، العدد 2 (30 يونيو/حزيران 2011)، ص ص. 51-55، 5ص.
الناشر
تاريخ النشر
2011-06-30
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Tumors of the salivary glands constitute an important area in the field of oral and maxillofacial pathology.
These tumors have a special status in human neoclassic and probably the most complex histopathology features of the body organs and being heterogeneous.
Pleomorphic adenoma (PA) is the most common benign ; and mucoepidermoid carcinoma(MEC) is the most common malignant salivary gland tumors.
Many investigations have showed that myoepithelial cells play a major role in the histogenesis of PA and may be important in many MECs.
The aims of the study are to determine the presence and distribution of myoepithelial cell related Immunomarkers Actin and S100 in PA and MEC and to explore the histogenesis of these tumors in relation to the above mentioned markers.
Materials and methods : Seventeen formalin fixed paraffin embedded tissue blocks of PA, and other fifteen tissue blocks of MEC were included in the study.
Diagnostic confirmation was performed through examination of hematoxylin and eosin sections.
Both tumors were immunohistochemical analyzed for the presence of actin and S100 protein.
Results : There was a positive immunoreactivity for the expression of actin in PA (100 %) with different score values , while for MEC, actin was negatively expressed in all of the cases (except in one case).
There was a highly statistical significant difference in the actin immunoexpression between the two tumors (p=0.000(.
There was a positive immunoreactivity for S100 protein expression in all of the cases of PA and MEC (100 %) with different score values ; however, there was no statistically significant difference in the S100 immunoexpression between them (p=0.545).
Conclusion : The myoepithelial cells are associated with the histogenesis of salivary PA, and the negative expression of actin in squamous, intermediate and mucous cells of MEC can be explained by the non-involvement of the myoepithelial cells in the histogenesis of this tumor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rashid, Farah S.& Majid, Ahlam H.. 2011. Immunohistochemical expression of actin and s100 in pleomorphic adenoma and mucoepidermoid carcinoma. Journal of Baghdad College of Dentistry،Vol. 23, no. 2, pp.51-55.
https://search.emarefa.net/detail/BIM-288165
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rashid, Farah S.& Majid, Ahlam H.. Immunohistochemical expression of actin and s100 in pleomorphic adenoma and mucoepidermoid carcinoma. Journal of Baghdad College of Dentistry Vol. 23, no. 2 (2011), pp.51-55.
https://search.emarefa.net/detail/BIM-288165
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rashid, Farah S.& Majid, Ahlam H.. Immunohistochemical expression of actin and s100 in pleomorphic adenoma and mucoepidermoid carcinoma. Journal of Baghdad College of Dentistry. 2011. Vol. 23, no. 2, pp.51-55.
https://search.emarefa.net/detail/BIM-288165
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendices : p. 55
رقم السجل
BIM-288165
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر