Oral manifestations, microbial study and enzyme analysis in patients with peptic ulcer

الملخص EN

Background : Peptic ulcer disease is one of the most common diseases affecting the gastrointestinal tract.

It causes inflammatory injuries in the gastric or duodenal mucosa, with extension beyond the sub mucosa into the muscular is mucosa (1).

The aims of this study was to determine the prevalence of oral manifestations in the peptic ulcer patients, isolate and identify different microorganism (aerobic, anaerobic and fungi), from oral micro flora from patients with peptic ulcer and detect the enzymes level in saliva including alkaline phosphates (ALP), total salivary protein (TSP).

and lactate dehydrogenate (LDH) in relation to peptic ulcer and comparison with healthy control.

Subjects, materials and method : The study included 35 patients with peptic ulcer (21male and 14 female) and group of 20 healthy control (7 male and 13 female).

Results : The most frequent oral manifestations in the patients with peptic ulcer, in our study was burning mouth syndrome, tooth erosion and aphthous ulcer, while angular chelitis, bad odor and white coated tongue, were fairly frequent.

The most frequent microorganisms in the patients with peptic ulcer, in our study was Staphylococcus aureus and Candida albicans.

A significant relationship of TSP and LDH enzymes in patients with peptic ulcer as compared to healthy control.

However, slightly increased levels of ALP in peptic ulcer patients as compared to healthy control , but no statistically relationship were established.

Conclusions : The most frequent oral manifestations in peptic ulcer patients were burning mouth syndrome, then tooth erosion and aphthous ulcer.

The prevalence of the oral manifestation in peptic ulcer patients increased within age.

High levels of total salivary protein and alkaline phosphates enzymes in patients with peptic ulcer than healthy control.

Low level of saliva LDH enzyme in patients with peptic ulcer than healthy control.

The frequent study showed a difference in oral microbial isolation between patients with peptic ulcer and healthy control ; therefore, frequent oral examination of patients with peptic ulcer is mandatory.