Serum and salivary levels of polyamines as potential biomarkers in the diagnosis of oral squamous cell carcinoma
المؤلفون المشاركون
Hamad, Abd al-Wahhab R.
Gaphor, Shanaz M.
al-Talabani, Nizar G.
المصدر
Journal of Baghdad College of Dentistry
العدد
المجلد 21، العدد 4 (31 ديسمبر/كانون الأول 2009)، ص ص. 48-53، 6ص.
الناشر
تاريخ النشر
2009-12-31
دولة النشر
العراق
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Back ground : Oral cancer is one of the prevalent cancers of the body and is one of the 10 most common causes of death.
Oral squamous cell carcinoma (OSCC) accounts for over 90 % of these tumors.
The aim of this study was designed to detect biochemical markers in serum and saliva of oral squamous cell carcinoma patients and to evaluate their validity in monitoring and diagnosis.
Patients and Methods: The level of polyamines in the serum and saliva of (30) patients with OSCC and (20) healthy individuals as control group was measured.
Polyamines (spermidine and spermine) were determined by high performance liquid chromatography (HPLC) in both serum and saliva of patients with OSCC and control group.
Results : the total serum and salivary polyamines level of OSCC were significantly higher than the control group (P < 0.001).
Both salivary and serum polyamines level were reliably accurate test in separating between OSCC patients and control group since the area under the ROC curve for both serum and salivary polyamines was one which is significantly higher (different ) from that of an equivocal test of 0.5.
There was significant difference in salivary spermine level among OSCC patients in relation to lesion status.
Spermine levels were reduced in recurrent lesion especially with metastases.
There were significant differences in serum polyamines level among OSCC patients in relation to duration of the disease (P < 0.05).
Conclusion : from the results of the presents study, it can be concluded that detection of polyamines in serum and saliva are useful and valuable diagnostic markers in diagnosis and early detection of OSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gaphor, Shanaz M.& al-Talabani, Nizar G.& Hamad, Abd al-Wahhab R.. 2009. Serum and salivary levels of polyamines as potential biomarkers in the diagnosis of oral squamous cell carcinoma. Journal of Baghdad College of Dentistry،Vol. 21, no. 4, pp.48-53.
https://search.emarefa.net/detail/BIM-288275
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gaphor, Shanaz M.…[et al.]. Serum and salivary levels of polyamines as potential biomarkers in the diagnosis of oral squamous cell carcinoma. Journal of Baghdad College of Dentistry Vol. 21, no. 4 (2009), pp.48-53.
https://search.emarefa.net/detail/BIM-288275
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gaphor, Shanaz M.& al-Talabani, Nizar G.& Hamad, Abd al-Wahhab R.. Serum and salivary levels of polyamines as potential biomarkers in the diagnosis of oral squamous cell carcinoma. Journal of Baghdad College of Dentistry. 2009. Vol. 21, no. 4, pp.48-53.
https://search.emarefa.net/detail/BIM-288275
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 52-53
رقم السجل
BIM-288275
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر