Clinico-pathological and prognostic significance of p53, Bcl-2 and Her-2 neu protein markers in colorectal cancer using tissue microarray
المؤلفون المشاركون
Munir, Manar M.
Ismail, Huda M.
al-Baradii, Manal M.
Khurshid, Ula
Tuni, Ahmad
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 19، العدد 1 (31 مارس/آذار 2007)، ص ص. 3-14، 12ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2007-03-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : The prognostic role of her-2/neu has been established in breast cancer but remains controversial in colorectal cancer (CRC).
Widespread genetic mutations in colorectal carcinogenesis exist on chromosome 17.
Her- 2/neu gene and the tumor suppressor gene p53 are both located on this chromosome.
Bcl-2 protein prolongs survival of a variety of cells by blocking apoptosis.
The aim of this study is to evaluate the relationship between the overexpression of p53, bcl-2 and her-2/neu protein markers and the clinico-pathologic characteristics of CRC, and their influence on survival rates. Patients and Methods: One hundred and four cases of CRC had paraffin blocks with representative tissue, and sufficient follow-up data.
They were arrayed and evaluated for protein marker expression using tissue microarray (TMA). Results: Ten (9.6%), 35 (33.7%) and 27 (26%) of the patients were her-2/neu, p53 and bcl-2 positive, respectively. None of the examined clinico-pathologic factors had a significant relation with her-2/neu overexpression. Patients with +ve bcl-2 had a significantly higher mean age (52.4±13.3years) compared to 45.4±14.4 years for bcl-2 negative patients, p=0.03.
Positive p53 was overexpressed in 20/44 (45.5%), 6/17 (35%), 9/43 (21%) cases of the colon, recto-sigmoid, and rectal sites, respectively, p=0.05. For the whole population, p53 overexpression had a significantly lower disease-free survival (DFS).
For patients with Dukes' stage B, overexpression of p53 protein had a significant reduced overall survival (OS) p=0.04, metastasis free survival (MFS) p=0.004, and DFS p=0.01 rates.
Expression of bcl-2 had a significantly better MFS p=0.001, while her-2/neu overexpression worsened the OS rate significantly, p=0.04. Conclusion: This study recommends the application of TMA technique for its economic importance and reliable quick throughput.
The results from this study also suggest that overexpression of p53, bcl-2, and her-2/neu protein markers appear to be useful in selecting a group of CRC patients with a worse prognosis and constitute potential candidates for adjuvant therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ismail, Huda M.& al-Baradii, Manal M.& Munir, Manar M.& Khurshid, Ula& Tuni, Ahmad. 2007. Clinico-pathological and prognostic significance of p53, Bcl-2 and Her-2 neu protein markers in colorectal cancer using tissue microarray. Journal of the Egyptian National Cancer Institute،Vol. 19, no. 1, pp.3-14.
https://search.emarefa.net/detail/BIM-28841
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Baradii, Manal M.…[et al.]. Clinico-pathological and prognostic significance of p53, Bcl-2 and Her-2 neu protein markers in colorectal cancer using tissue microarray. Journal of the Egyptian National Cancer Institute Vol. 19, no. 1 (Mar. 2007), pp.3-14.
https://search.emarefa.net/detail/BIM-28841
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ismail, Huda M.& al-Baradii, Manal M.& Munir, Manar M.& Khurshid, Ula& Tuni, Ahmad. Clinico-pathological and prognostic significance of p53, Bcl-2 and Her-2 neu protein markers in colorectal cancer using tissue microarray. Journal of the Egyptian National Cancer Institute. 2007. Vol. 19, no. 1, pp.3-14.
https://search.emarefa.net/detail/BIM-28841
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 11-14.
رقم السجل
BIM-28841
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر