Local expression of MMP-7 in oral cancer

الملخص EN

Background : squamous cell carcinoma of the oral cavity (OSCC) is a highly invasive neoplasm.

Many MMPs play role in human cancer invasion and metastases Aim : Estimating The MMp-7 expression level in HPV-16 positive and HPV-16 negative OSCC paraffin embedded sections. Method : biopsies from thirty three patients with oral squamous cell carcinoma (OSCC) were obtained and investigated for the presence of HPV-16 RNA with the application of ISH and the MMP-7 expression level using IHC.

Results : Expression level of MMP-7 found to be high in OSCC sections 29 (87.8 %) cases with no significant difference in its expression level between HPV-16 positive and HPV-16 negative OSCC cases p= 1.00. Conclusion : MMp-7 found to be expressed in high level in OSCC with no significant relevance to HPV.