Comparison between light and electron microscopic findings in 30 patients with lupus nephritis
المؤلفون المشاركون
Owji, S. M.
Nezhad, S. Torabi
Rahehagh, R.
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 9، العدد 1 (31 يناير/كانون الثاني 2007)، ص ص. 9-16، 8ص.
الناشر
تاريخ النشر
2007-01-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: The kidney biopsy specimen is used for initial diagnosis of patients with SLE who at the time of biopsy lack either diagnostic clinical manifestation and or serological markers.
Another role is evaluation of renal dysfunction in transplanted patients when lupus has occurred in renal allograft.
The aim of this study is correlating the findings of light, immunofluorescent and electron microscopy in thirty patients with lupus nephritis. Methods: The kidney biopsies of thirty patients with SLE were studied for purpose of correlating the findings of light, immunofluorescent and electron microscopy.
We studied 30 parameters in light microscopy sections, 5 parameters in semi -thin and EM sections , and IgG, IgM, IgA, C3, C4 and fibrinogen in different structures of specimens by immunofluroscent microscopy.
The P value and measurement of agreement of kappa was calculated. Results: In 25 cases LM and EM correlated completely including lupus nephritis class, activity and chronicity indices and presence or absence of immune complex deposition.
In 5 cases discrepancy between Light Microscopy and Electron Microscopy diagnosis was found. Three cases were classified as class III according to LM and class II by EM.
LM reevaluation of all three cases showed focal and segmental endocapillary cell proliferation with neutrophilic infiltration.
We found that LM study is cornerstone in the focal lesions because of the limited inclusion of glomeruli in EM.
One case of class IV by LM, in EM shows massive (grade III) sub-epithelial depositions and grade I sub endothelial deposition and was classified it as Class V + VI.
In LM, findings cellular crescent in six glomeruli, severe endocapillary cell proliferation with activity index of (16/24) were detected.
So the correct diagnosis was Class V + VI.
The last case classified as IV in LM classification and revealed moderate mesangial cell proliferation with obliteration of lumens.
In EM, we had three glomeruli which all showed mesangial cell proliferation, grade II mesangial deposition, with one focus of small (grade I) sub endothelial deposition.
According to the above-mentioned findings the EM class of patient was class II. Conclusion: We found that there is agreement between EM and semi-thin sections for detection of exact site of depositions as well as their grading.
Study of semi-thin sections by LM can demonstrate the deposits that are observed on EM.-
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nezhad, S. Torabi& Owji, S. M.& Rahehagh, R.. 2007. Comparison between light and electron microscopic findings in 30 patients with lupus nephritis. Iranian Red Crescent Medical Journal،Vol. 9, no. 1, pp.9-16.
https://search.emarefa.net/detail/BIM-29120
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nezhad, S. Torabi…[et al.]. Comparison between light and electron microscopic findings in 30 patients with lupus nephritis. Iranian Red Crescent Medical Journal Vol. 9, no. 1 (Jan. 2007), pp.9-16.
https://search.emarefa.net/detail/BIM-29120
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nezhad, S. Torabi& Owji, S. M.& Rahehagh, R.. Comparison between light and electron microscopic findings in 30 patients with lupus nephritis. Iranian Red Crescent Medical Journal. 2007. Vol. 9, no. 1, pp.9-16.
https://search.emarefa.net/detail/BIM-29120
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 16
رقم السجل
BIM-29120
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر