Toxic potential of ethanolic extract of acacia nilotica (garad)‎ in rats

الملخص EN

Objective: The study aimed to investigate acute and sub-acute toxic potential of ethanolic extract of Acacia nilotica (Garad) in rats. Methods : LD50 of Garad was determined.

Changes in behavioral response, induced by sub-acute treatments were recorded.

Elevated urea, cretonne, ALT (GPT) and AST (GOT) in plasma were taken as evidence for impaired kidney and liver function. Results : LD50 of Garad extract was found to be 215.36 mg / kg (124.84 – 317.47).

Regarding sub-acute treatment, observations on seventh and fourteenth days showed slight to moderate sedation at various doses.

On day 21 no behavioral changes were recorded.

However, a treatment for three weeks induced significant elevation in urea and ALT (p < 0.05). Conclusion : It can be concluded that the ethanolic extract of Garad has got some toxicity when administered sub acutely and intraperitoneally in rats, particularly at high dose (60 mg / kg).