HER2 over expression in malignant palpable breast lumps of pre and postmenopausal women attending rick

الملخص EN

Back ground : human Epidermal growth factor Receptor 2 (HER-2 / neu) over expression in breast cancer is associated with poor outcome and decrease disease free survival (DFS).

The aim of this study was to evaluate the over expression of HER2 / neu among premenopausal and postmenopausal females presented with malignant palpable breast lumps to Radio Isotope Center Khartoum (RICK). Methods : the study was a case-control conducted among patients attending Radiation Isotopes Centre Khartoum (RICK).

A total of 328 women were randomly selected.

Data were collected by a pre coded, pre tested questionnaire.

Tissue biopsies of breast lumps had been analyzed using immunohistochemical techniques for HERR-2 / neu over expression and its relation to other prognostic factors was evaluated. Results : HER-2 / neu + vein first pregnancy at 23 years, were 32 (41 %) in the cases, 6 (35 %) in the controls of premenopausal women, and 21(44 %) in the cases, 5 (38 %) in the controls of postmenopausal women.

HER-2 / neu + veexpression in relation to age at menarche 12 years was 39 (51 %) in the cases, 7 (39 %) in the controls of premenopausal women, and 36 (56 %) in the cases, 7 (45 %) in the controls of postmenopausal women.

HER-2 / neu+ vein relation to Body Mass Index 29 < kg/m2 showed 7 (37%) in the cases, 2 (33%) in the controls of premenopausal women (x2 = 0.024), and 8 (38 %) in the cases, 2 (40 %) in the controls of postmenopausal women (x2 = 0.006).

HER-2 / neu+ veexpression in relation to history of abortion or miscarriage (ever) was found to be 21 (39 %) in the cases, 4 (33 %) in the controls of premenopausal women, and 18 (44 %) in the cases, 3 (33 %) in the controls among postmenopausal women.

HER-2/neu+ veexpression in relation to the history of breast cancer in a first degree relatives was 3 (25 %) in the cases, 1 (50 %) in the controls of premenopausal women, and 4 (22 %) in the cases, 2 (28 %) in the controls of postmenopausal women.

HER-2/neu+ veexpression in relation to the use of oral contraceptives was 3 (37 %) in the cases, 1 (50 %) in the controls among premenopausal women, and 3 (27 %) in the cases, 1 (50 %) in the controls of postmenopausal women. Conclusion : the study confirmed an etiological association between HER2 / neu+ve and HER2 / neu ve and age at first pregnancy ^ 23 years, age of menarche at _ 12 years, abortion or miscarriage in premenopausal and post-menopausal Sudanese women, while an etiological association was confirmed between HER2/ neu + ve and HER2 / neu – ve, and BMI in pre-menopausal women, and the family history of cancer in post-menopausal women.