Evaluation of the effects of simvastatin in reduction of panel-reactive antibody (PRA) levels in patients with end-stage renal disease awaiting renal transplantation
المؤلفون المشاركون
Naghibi, Massih
Zahid, Nargesosadat
Nazemian, Fatimah
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 23، العدد 2 (30 إبريل/نيسان 2012)، ص ص. 306-310، 5ص.
الناشر
تاريخ النشر
2012-04-30
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
This study was undertaken to assess the effect of simvastatin in the reduction of panel-reactive antibody (PRA) levels in patients with end-stage renal disease (ESRD) awaiting renal transplantation.
During the 1-year period from September 2007 to August 2008, 60 ESRD patients with PRA levels more than 30 % were enrolled into the study.
Each patient was given oral simvastatin 10 mg / day as the initial dose.
After one month, in those patients who did not respond, the dose was increased to 20 mg/day.
Again, at the end of two months, if there was no response, the dose was further raised to 40 mg / day of simvastatin.
The appropriate response to the treatment was defined as serum PRA levels getting reduced to less than 30 %.
Among the 60 patients who were enrolled in the study, three cases were excluded due to side-effects of the drug and 57 patients remained in our study.
The mean age was 42.8 ± 28.2 years (range 18–75).
Among these, 34 (59.6 %) were females.
Before the study, the PRA levels were between 30 and 100 (mean ± SD: 60.4 % ± 20 %).
After the administration of simvastatin, a significant decrease in PRA levels was seen in our patients (P < 0.0001).
In patients who had baseline PRA less than 40 %, the PRA dropped to below 30% in 69.2 % of the cases with 10 mg simvastatin.
In those who had baseline PRA more than 40 %, a similar reduction was seen only in 15.9 % of the cases.
However, in those who did not respond initially to 10 mg of simvastatin, statistically significant reductions were seen after the administration of 20 mg and, if needed, 40 mg of simvastatin (P = 0.001).
In conclusion, simvastatin can be a useful drug in ESRD patients to lower the PRA levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zahid, Nargesosadat& Nazemian, Fatimah& Naghibi, Massih. 2012. Evaluation of the effects of simvastatin in reduction of panel-reactive antibody (PRA) levels in patients with end-stage renal disease awaiting renal transplantation. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 2, pp.306-310.
https://search.emarefa.net/detail/BIM-292808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zahid, Nargesosadat…[et al.]. Evaluation of the effects of simvastatin in reduction of panel-reactive antibody (PRA) levels in patients with end-stage renal disease awaiting renal transplantation. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 2 (Apr. 2012), pp.306-310.
https://search.emarefa.net/detail/BIM-292808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zahid, Nargesosadat& Nazemian, Fatimah& Naghibi, Massih. Evaluation of the effects of simvastatin in reduction of panel-reactive antibody (PRA) levels in patients with end-stage renal disease awaiting renal transplantation. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 2, pp.306-310.
https://search.emarefa.net/detail/BIM-292808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 309-310
رقم السجل
BIM-292808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر