Interstitial nephritis with moderate-to-heavy proteinuria : an unusual combination
المؤلفون المشاركون
Usha, N. I.
Ghosh, Biplab
Singh, Rana Gopal
Behura, Sanjeev Kumar
Soni, Ashutosh
Sharatchandra, Lou Krakpam
Singh, Shivendra
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 23، العدد 2 (30 إبريل/نيسان 2012)، ص ص. 397-402، 6ص.
الناشر
تاريخ النشر
2012-04-30
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Interstitial nephritis with proteinuria > 1 g / day is uncommon and almost always the result of drug-induced ATIN with an associated minimal change glomerulonephritis (GN).
Here we present a series of five unusual cases of interstitial nephritis without GN but with proteinuria 1 < g / day, and they were identified from renal biopsies done from February 2008 to March 2009.
Out of 236 patients who underwent renal biopsy, only five met the inclusion criteria.
Three patients presented with edema and two with oliguria, while none had frank hematuria, fever, arthralgia, skin rash or history of exposure to no steroidal anti-inflammatory drugs, analgesics, antibiotics, allopurinol, or Chinese herb before presentation.
Urinalysis revealed hematuria in two patients, pyuria in three and nephrotic range proteinuria in two.
All had normal complement levels and were negative for antinuclear antibodies, Anti-dsDNA antibody, and antineutrophil cytoplasmic antibodies.
Clinical diagnosis was nephrotic syndrome in two patients, the third had diagnosis of rapidly progressive GN, the fourth had HIV associated nephropathy, and the fifth had unexplained advanced renal failure.
Though three patients had renal dysfunction only one required dialysis.
Light microscopy of renal biopsies revealed granulomatous interstitial nephritis in three patients and small vessel vasculitis in two of them.
One patient had no granulomatous interstitial nephritis along with vasculitis.
Acute interstitial nephritis was the only finding in one patient.
In conclusion, patients with interstitial nephritis can present with moderate-to-heavy proteinuria probably due to cytokine-like permeability increasing factor secreted by inflammatory cells in the interstitium.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghosh, Biplab& Singh, Rana Gopal& Usha, N. I.& Behura, Sanjeev Kumar& Soni, Ashutosh& Sharatchandra, Lou Krakpam…[et al.]. 2012. Interstitial nephritis with moderate-to-heavy proteinuria : an unusual combination. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 2, pp.397-402.
https://search.emarefa.net/detail/BIM-293011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghosh, Biplab…[et al.]. Interstitial nephritis with moderate-to-heavy proteinuria : an unusual combination. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 2 (Apr. 2012), pp.397-402.
https://search.emarefa.net/detail/BIM-293011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghosh, Biplab& Singh, Rana Gopal& Usha, N. I.& Behura, Sanjeev Kumar& Soni, Ashutosh& Sharatchandra, Lou Krakpam…[et al.]. Interstitial nephritis with moderate-to-heavy proteinuria : an unusual combination. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 2, pp.397-402.
https://search.emarefa.net/detail/BIM-293011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 401-402
رقم السجل
BIM-293011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر