Safety immunogenicity and possible efficacy of immunochemotherapy of persistent post kala-azar dermal leishmaniasis
المؤلفون المشاركون
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المصدر
Sudanese Journal of Dermatology
العدد
المجلد 3، العدد 2 (30 يونيو/حزيران 2005)، ص ص. 62-72، 11ص.
الناشر
تاريخ النشر
2005-06-30
دولة النشر
السودان
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Post kala-azar dermal leishmaniasis (PKDL) is a common skin condition that follows successful treatment of visceral leishmaniasis (VL) in Sudanese patients.
Lesions persist for years in 15 % of patients and are viewed as reservoirs for the disease.
Drug treatment is protracted, toxic and costly.
Cure is strongly correlated with conversion in the leishmanin skin test.
Objective of the study : To determine safety, immunogenicity and possible efficacy of Alum-precipitated autoclaved L.
major + BCG VL candidate vaccine combined with sodium stibogluconate (SSG) in patients with persistent PKDL.
Methodology and results : Following informed consent, the vaccine mixture was administered in a stepwise manner as follows : 5 patients received a single intradermal injection of 10 μg, 5 patients received a single dose of 100 μg and 2 patients received 4 doses of 100 μg at weekly intervals.
Subsequently, the three groups of patients received means of 63.0 ± 8.0, 53.0 ± 5.0 and 40 days courses of SSG treatment respectively and were cured.
Side effects were minimal and were confined to the vaccine injection site.
Following completion of the safety study, eight patients were injected with 4-6 vaccine doses of 100 μg / dose at weekly intervals in combination with SSG.
Patients were closely followed up in hospital, with minimal side effects and complete clearance of the skin rash in forty days.
Conclusion : Alum / ALM + BCG vaccine mixture plus SSG was safe and was apparently effective in healing persistent PKDL lesions.
SSG treatment duration could be shortened with the SSG / vaccine combination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Musa, Ahmad Madwi& Ismail, A.& al-Hasan, Ibrahim Muhammad& Fesharki, H.& Khamesipour, A.& Mudabbir, F.…[et al.]. 2005. Safety immunogenicity and possible efficacy of immunochemotherapy of persistent post kala-azar dermal leishmaniasis. Sudanese Journal of Dermatology،Vol. 3, no. 2, pp.62-72.
https://search.emarefa.net/detail/BIM-293872
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Musa, Ahmad Madwi…[et al.]. Safety immunogenicity and possible efficacy of immunochemotherapy of persistent post kala-azar dermal leishmaniasis. Sudanese Journal of Dermatology Vol. 3, no. 2 (Jun. 2005), pp.62-72.
https://search.emarefa.net/detail/BIM-293872
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Musa, Ahmad Madwi& Ismail, A.& al-Hasan, Ibrahim Muhammad& Fesharki, H.& Khamesipour, A.& Mudabbir, F.…[et al.]. Safety immunogenicity and possible efficacy of immunochemotherapy of persistent post kala-azar dermal leishmaniasis. Sudanese Journal of Dermatology. 2005. Vol. 3, no. 2, pp.62-72.
https://search.emarefa.net/detail/BIM-293872
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 69-72
رقم السجل
BIM-293872
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر