Ipsilateral in-breast tumor relapse after breast conservation therapy : true recurrence versus new primary tumor
المؤلفون المشاركون
Abd Allah, Hassan M.
Munir, Manar M.
Lutayf, Muhammad M.
Abu Bakr, Amani
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 18، العدد 3 (30 سبتمبر/أيلول 2006)، ص ص. 183-190، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2006-09-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background and Purpose : Ipsilateral breast tumor relapse (IBTR) occurs in approximately 8-20 % of women 10 years after breast conservation therapy (BCT).
The aim of this study is to classify ipsilateral breast tumor relapses in patients treated with conservative surgery and radiation therapy as true recurrences or new primary and to show the clinical significance of classification into these two types of recurrences.
Patients and Methods : Out of 267 patients treated at National Cancer Institute, Cairo University in the period extending from 1993 to 2000, 29 patients have experienced ipsilateral tumor relapse as the first site of recurrence.
These relapses were classified as true recurrence if it was located within 3cm of the primary tumor bed and was of the same histologic subtype.
All other ipsilateral breast tumor relapses were considered as new primary.
The patients were followed-up until January 2005.
Results : After a mean follow-up period of 7.9 2.6 years following the original diagnosis, the overall ipsilateral breast tumor relapse rate was 9.6 % (29 / 267).
Relapses were classified as TR in 21 patients (72.4 %) and were considered as a new primary in 8 cases (27.6 %).
Patients diagnosed with a new primary had a longer mean time to breast relapse (6.09 years for NP Vs 3.09 years for TR, p < 0.001) and were significantly younger than true recurrence patients (38.38 years Vs 47.54 years, p = 0.006).
Patients with a new primary had a 10- year overall survival of 87.5 % ; whereas, it was 61.90 % for TR cases (p = 0.13).
Conclusions : It appears that a significant portion of patients who experience ipsilateral breast tumor relapse following conservative surgery and radiation therapy have new primary tumors as opposed to true recurrences.
Patients with a new primary had better survival rates than those with true recurrence.
Distinguishing new primary breast carcinoma from local disease recurrence may have importance in therapeutic decisions and chemoprevention strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd Allah, Hassan M.& Lutayf, Muhammad M.& Abu Bakr, Amani& Munir, Manar M.. 2006. Ipsilateral in-breast tumor relapse after breast conservation therapy : true recurrence versus new primary tumor. Journal of the Egyptian National Cancer Institute،Vol. 18, no. 3, pp.183-190.
https://search.emarefa.net/detail/BIM-29440
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd Allah, Hassan M.…[et al.]. Ipsilateral in-breast tumor relapse after breast conservation therapy : true recurrence versus new primary tumor. Journal of the Egyptian National Cancer Institute Vol. 18, no. 3 (Sep. 2006), pp.183-190.
https://search.emarefa.net/detail/BIM-29440
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd Allah, Hassan M.& Lutayf, Muhammad M.& Abu Bakr, Amani& Munir, Manar M.. Ipsilateral in-breast tumor relapse after breast conservation therapy : true recurrence versus new primary tumor. Journal of the Egyptian National Cancer Institute. 2006. Vol. 18, no. 3, pp.183-190.
https://search.emarefa.net/detail/BIM-29440
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : pp. 189-190
رقم السجل
BIM-29440
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر