Symptomatic side effects of combined oral contraceptive pills

الملخص EN

jtfpvospective study was carried out during nine-month period (from /<* of (December 2001 until the end of Guguat 2002) in Skuvah Maternity.

and Children teaching, SiaspitaL She aim, id to assess the timing, ptequency and severity of symptomatic effect) of combined anal contraceptive (COC) users specifically to compote 21 days of active.

pill intervals with 7 days of hormone- ptee intervals in both current (GiSQ, user (ok >12 months) and new- users (QiSQ, user fox 3 months).

Current users had pattern, of symptom* that were observed significantly.

worse dwung hormone-ptee internal than dwung the three active-pill weeks fat both Pl and 2nd cycles.

57%, and 56%, of them experienced mild pelvic pain dwung ptee period versus 19% and 16%, dwung active-pills weeks in both cycles vespectively.

(9=0.001), while, moderate to severe pelvic pain, the corresponding percentages were 22%, and 22°/0 versus 9% and 8%, (9-0.042).

So* Nausea, the percentages were 48%, and 46%, versus 31%0 and 30%o.

Sot bloating the comes ponding percentages were.

46%0 and 46°/0 versus 18% and 16%, (9>>0.C001) and for breast tenderness the corresponding percentage in free period were.

29% and 29%, versus 16%, and 15%, in active pill interval in both cycles vespectively (9=0.0004).

She veverse was true when other symptoms were assessed iihe headache and mood changes.

(Regarding headache the corresponding percentages were 35%, and 33%, during free period versus 60%, and 58%, during active pill interval in bath cycles vespectively, and far mood changes, the percentages were 21%0 and 19%, versus 50%, and 47%, vespectively.

Similar patterns far all pvevioua sumptoms were observed in new start &5C users in both cycle 1 and 2 for pelvic pain, nausea, bloating and breast tenderness.

Shese symptoms increased and became worse during hormone ptee interval while headache and mood changes became more severe during active hormone period than during hormone free interval.

Siveahthrough vaginal bleeding occurred more frequently in new start CSSC in comparison to current users.

She percentages were 20%g and 16%, versus 5% and 3% in both cycles vespectively.

Menstrual flaw decreased significantly in current users in comparison to new start CISC (5%, and 16%,) vespectively (SaMe-4).

Shu study confirmed that most symptoms assessed were significantly-worse during the 7 day hoKmone-ptee interval than during the 21 day of hormone-containing pills.