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Rolactin and leptin : inter-relation in pituitary adenoma
المؤلفون المشاركون
Zaghlul, Sahar G.
al-Shahidi, Khadijah E.
Asal, Najwa M.
المصدر
Egyptian Journal of Applied Endocrinology
العدد
المجلد 22، العدد 1-2 (31 يوليو/تموز 2004)، ص ص. 15-26، 12ص.
الناشر
الجمعية المصرية للغدد الصماء التطبيقية
تاريخ النشر
2004-07-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : The pituitary adenoma, prolactinoma has various biologic behaviors with different endocrinological and neurological manifestations.
Leptin, a peptide hormone of obesity gene, has recently been demonstrated in human pituitary.
It has been observed that, weight gain is associated with prolactinoma and weight loss occurs with normalization of prolactin level.
So we aimed to study serum leptin and prolactin in patients with prolactinoma and investigate their relation to body weight, tumor type (micro or macroadenoma) and invasion to the surrounding structures.
Methods : The study included 25 patients with prolactinoma and 10 healthy controls.
Seventeen patients were females and 8 were males, 18 had microadenoma and 7 had macroadenoma.
All patients underwent clinical evaluation with assessment of body mass index (BM1), serum prolactin and leptin measurement, MRI and visual field assessment.
Invasion of the tumor was assessed by both MRI and visual field examination.
Results : Prolactin level increased in macroadenoma > microadenoma (mean value ± SD 442.85 ± 258.8 vs 153.33 ± 33.95ng / ml), in invasive > non- invasive tumor(510.0 ± 283.72 vs 165.5 ± 49.97 ng / ml) and in males > females(370 ±280.2 ng / mlj.
Prolactin level was correlated with age of the patients and tumor size but didn't correlate with BMI.
BM1 was increased in prolactinoma (31.11± 1.89 in female patients, 29.56 ± 1.59 in male patients and 24.3 ± 1.76 kg/m2 in controls).
Serum leptin was elevated in prolactinoma patients (17.14 ± 5.55 in macroadenoma, 17.44 ±2.17 in microadenoma vs 7.9 ±3.17ng / ml in controls) and in females more than males(18.88 ± 2.73 vs 14.12 ± 1.82 ng / ml), but didn't correlate to age of the patients, tumor size or prolactin level.lt was significantly correlated to BMI.
Conclusion.'Weight gain and increase BMI were associated with prolactinoma regardless of the mass of tumor and prolactin level, but related to serum leptin level.
While manifestations of tissue invasion was related to prolactin and not leptin levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zaghlul, Sahar G.& al-Shahidi, Khadijah E.& Asal, Najwa M.. 2004. Rolactin and leptin : inter-relation in pituitary adenoma. Egyptian Journal of Applied Endocrinology،Vol. 22, no. 1-2, pp.15-26.
https://search.emarefa.net/detail/BIM-295053
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zaghlul, Sahar G.…[et al.]. Rolactin and leptin : inter-relation in pituitary adenoma. Egyptian Journal of Applied Endocrinology Vol. 22, no. 1-2 (Jul. 2004), pp.15-26.
https://search.emarefa.net/detail/BIM-295053
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zaghlul, Sahar G.& al-Shahidi, Khadijah E.& Asal, Najwa M.. Rolactin and leptin : inter-relation in pituitary adenoma. Egyptian Journal of Applied Endocrinology. 2004. Vol. 22, no. 1-2, pp.15-26.
https://search.emarefa.net/detail/BIM-295053
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendices : p. 23-26
رقم السجل
BIM-295053
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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