Study of plasma adiponectin level in cases of thyroid dysfunction associated with body weight disorder

الملخص EN

Background : Adipoiiectin is a recently discovered adipocytokine.

It is a 244 amino acid protein, the product of the apMl gene which is specially and highly expressed in human adipose cells.

Adiponectin reduces insulin resistance, plays a protective role against atherosclerosis.

Plasma adiponectin levels were found to be decreased in patients with obesity, type! diabetes, insulin resistance, dyslipidaemia and cardiovascular disease.

It was found that thyroid dysfunction is associated with minor changes in body weight and fat mass, and thyroid hormones affect adipose tissue secretion regardless of tlie thyroid stattis.

Objective : Tire aim of the present study is to detect tlie relationship between thyroid dysfunction, body weight disorders and plasma adiponectin level.

Study Design : the present study was conducted on 60 individuals all have body weight disorders.

Tlie mean age was 40.25 ± 8.17 years, subjects were divided into 4 groups according to tlie thyroid status: 20 hypothyroid patients, 20 hyperthyroid patients, 10 obese euthyroid subjects and 10 lean euthyroid subjects (taken as control).

All were subjected to full history taking, thorough clinical examination with special emphasis on the manifestations of thyroid dysfunction, calculation of EMI and laboratory workup including total T3 level, free T4 level, TSH level, and serum adiponectin level measurement.

Results : Hypothyroid patients have a higher BMI compared to hyerthyriod patients.

Plasma adiponectin level is inversely proportionate to BMI in all groups.

There is no relationship between plasma adiponectin level and the thyroid hormones in different thyroid states.

Conclusion: Although adiponectin level is higher in hyperthyroid than in hypothyroid state, there is no significant correlation between adiponectin level and T3, FT4, TSH level.

Tfiere was negative correlation between adiponectin level and BMI in hypo, hyper, and euthyroid states.