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Aberrant lymphoid antigen expression in acute myeloid leukemia in saudi arabia
المؤلفون المشاركون
al-Sisi, Azzah H.
al-Mashari, Mayy A.
Basyuni, Wafa Y.
al-Suwayyid, Azizah F.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 18، العدد 3 (30 سبتمبر/أيلول 2006)، ص ص. 244-249، 6ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2006-09-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Immunophenotyping improves both accuracy and reproducibility of acute leukemia classification and is considered particularly useful for identifying aberrant lineage association of acute leukemia, biphenotypic and bilineal acute leukemia, as well as monitoring minimal residual disease.
Some immunophenotypes correlate with cytogenetic abnormalities and prognosis.
The Aim of Our Study : Is to determine aberrant lymphoid antigen expression in Saudi acute myeloid leukemia (AML), correlate them with FAB subtypes, evaluate early surface markers CD7 and CD56, and to investigate the role of cytoplasmic CD79a (a B cell marker that is assigned a high score of 2.0 in the WHO classification).
Patients and Methods : Thirty four newly diagnosed AML cases were included in this study, 47 % showed aberrant lymphoid antigen expression.
CD9 was the most frequently expressed lymphoid antigen (29.4 %) followed by CD7 & CD19 (11.8 %), CD4 (8.8 %) and CD22 (2.9 %).
CD9 was expressed in 3 / 6 (50 %) of M3 cases, CD7 was expressed in 11.8 % and was mostly confined to FAB M1 and M2 and associated with immature antigens CD34, HLA-DR and TdT.
CD56 was expressed in 7 / 34 (20.6 %) cases, three of these cases (42.9 %) belonged to the monocytic group.
CD56 was also detected in 2 cases with 11q23 rearrangement.
CD56 was expressed in 2 / 7 (28.6 %) M2 cases, and was associated with t (8 ; 21) (q22 ; q22) together with CD19.
Co-expression of CD56 and CD7 was detected in 2.9 % of the cases.
CD79a was expressed in one case together with CD19, diagnosed as acute biphenotypic leukemia, and was associated with t(8 ; 21) (q22 ; q22).
Conclusion : Minimal residual disease in AML is very difficult to trace, detection of aberrant expression of lymphoid antigens will make it easier.
The high score given to CD79a by EGIL is questionable based on cytogenetic classification.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sisi, Azzah H.& al-Mashari, Mayy A.& Basyuni, Wafa Y.& al-Suwayyid, Azizah F.. 2006. Aberrant lymphoid antigen expression in acute myeloid leukemia in saudi arabia. Journal of the Egyptian National Cancer Institute،Vol. 18, no. 3, pp.244-249.
https://search.emarefa.net/detail/BIM-29525
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sisi, Azzah H.…[et al.]. Aberrant lymphoid antigen expression in acute myeloid leukemia in saudi arabia. Journal of the Egyptian National Cancer Institute Vol. 18, no. 3 (Sep. 2006), pp.244-249.
https://search.emarefa.net/detail/BIM-29525
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sisi, Azzah H.& al-Mashari, Mayy A.& Basyuni, Wafa Y.& al-Suwayyid, Azizah F.. Aberrant lymphoid antigen expression in acute myeloid leukemia in saudi arabia. Journal of the Egyptian National Cancer Institute. 2006. Vol. 18, no. 3, pp.244-249.
https://search.emarefa.net/detail/BIM-29525
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : pp. 248-249
رقم السجل
BIM-29525
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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