Acute oral toxicity (LD50) and target organ effects of locally made chitosan and chitosan-indomethacin conjugate in mice
المؤلفون المشاركون
Ahmad, Jawad H.
Thajil, Ikhlas F.
al-Hakim, Muhammad H. H.
المصدر
The Medical Journal of Basrah University
العدد
المجلد 21، العدد 1 (30 يونيو/حزيران 2003)، ص ص. 15-19، 5ص.
الناشر
تاريخ النشر
2003-06-30
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Chitosan which is a deacetylated chitin has a wide medical and pharmaceutical applications beingprepared in a previous study in our laboratory and being modified to form a covalently linked chitosan-indomethacin conjugate for the sake of formulation of a sustained release indomethacin capsules.
Chitosan alone and chitosan-indomethacin conjugate were both being tested for their acute toxicity in mice.
The animals were observed for signs of reaction and a post mortem examination was performed in mice, which were given chitosan orally, no death has been observed during the first 24 hours or during the rest of the observation periods, while mice which were given chitosan-indomethacin conjugate, the mortality seems to is dose related.
It was 60 % at a dose of 5 g/Kg and increased to 80 % and 100 % at 7.5 g/Kg and 10 Gj Kg respectively.
U) 50 for chitosan-indomethacin conjugate was found to be 4.8 gj Kg.
Other criteria examined in addition to mortality include body weight, diet and water consumption and organs (liver, large and small intestine, kidney) gross and by histopathology.
There were no noticeable changes in these criteria after the administration of chitosan alone or chitosan-indomethacin conjugate compared to control groups.
Chitosan and chitosan-indomethacin conjugate prepared locally in our laboratory are safe enough to be used in pharmaceutical formulations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Thajil, Ikhlas F.& Ahmad, Jawad H.& al-Hakim, Muhammad H. H.. 2003. Acute oral toxicity (LD50) and target organ effects of locally made chitosan and chitosan-indomethacin conjugate in mice. The Medical Journal of Basrah University،Vol. 21, no. 1, pp.15-19.
https://search.emarefa.net/detail/BIM-296457
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Thajil, Ikhlas F.…[et al.]. Acute oral toxicity (LD50) and target organ effects of locally made chitosan and chitosan-indomethacin conjugate in mice. The Medical Journal of Basrah University Vol. 21, no. 1 (2003), pp.15-19.
https://search.emarefa.net/detail/BIM-296457
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Thajil, Ikhlas F.& Ahmad, Jawad H.& al-Hakim, Muhammad H. H.. Acute oral toxicity (LD50) and target organ effects of locally made chitosan and chitosan-indomethacin conjugate in mice. The Medical Journal of Basrah University. 2003. Vol. 21, no. 1, pp.15-19.
https://search.emarefa.net/detail/BIM-296457
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 18-19
رقم السجل
BIM-296457
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر