HLA-C polymorphisms in two cohorts of donors for bone marrow transplantation

الملخص EN

The typing for HLA-C in transplantation was rather neglected in the past.

However, several recent studies have emphasized its role in transplantation and its association with the outcome.

Serological typing of HLA-C could identify only a limited number of HLA-C antigens, resulting in a number of HLA-C blanks.

This was mainly due to the low expression of surface HLA-C and the small number of available specific anti-sera.

Performing molecular methods has identified new HLA-C alleles and filled the blank of most serological typed antigens.

In this study, we compared serological and molecular typing of HLA-C in two cohorts of healthy Saudis.

Our serological typing method identified HLA-C1-7 with different frequencies, 23.5 % of the alleles were not identified and thus defined as blank.

Using the SSP molecular method, all samples were typed and all alleles were defined.

Both methods showed that C * 07 and C * 06 have the highest frequency in the Saudi population.

Our study emphasizes the importance of molecular methods in identifying all possible HLA-C alleles.