Genetic Polymorphism of Folate and Methionine Metabolizing Enzymes and their Susceptibility to Malignant Lymphoma
المؤلفون المشاركون
Habib, Imad Izzat
Aziz, Muna
Qutub, Majd H.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 17، العدد 3 (30 سبتمبر/أيلول 2005)، ص ص. 184-192، 9ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2005-09-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Folate and methionine metabolism is involved in DNA synthesis and methylation.
Polymorphisms in the genes of folate metabolism enzymes have been associated with some forms of cancer.
In the present study, 2 polymorphisms were evaluated for a folate metabolic enzyme, methylene-tetrahydrofolate reductase (MTHFR), and one was evaluated for methionine synthase (MS). The 2 polymorphisms MTHFR 677 C?T and MTHFR 1298 A?C, are reported to reduce the enzyme activity, which causes intracellular accumulation of 5, 10- methylene-tetrahydrofolate and results in a reduced incidence of DNA double strand breakage.
The MS 2756 A?G polymorphism also reduces the enzyme activity and results in the hypomethylation of DNA. Patients and Methods: To test this hypothesis, genetic polymorphisms in the folate metabolic pathway were investigated using the DNA from a case-control study on 31 patients having malignant lymphoma from the Oncology Outpatient Clinic of the New Children's Hospital, Cairo University and 30 controls who were actually normal children attending for vaccination to the same hospital. Results: We found that there is a higher susceptibility with the MTHFR 677CC and MTHFR 1298 AA genotypes (OR=4.3, 95% CI 1.12-16).
When those harbor at least one variant allele in either polymorphism of MTHFR they were defined as reference.
For the MS 2756 AG genotype polymorphism there was also a higher susceptibility to developing malignant lymphoma (OR=2.6; 95% CI 1.1- 6.4). Conclusion: Results suggest that folate and methionine metabolism may play an important role in the pathogenesis of malignant lymphoma.
Further studies to confirm this association and detailed biologic mechanisms are now required.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Habib, Imad Izzat& Aziz, Muna& Qutub, Majd H.. 2005. Genetic Polymorphism of Folate and Methionine Metabolizing Enzymes and their Susceptibility to Malignant Lymphoma. Journal of the Egyptian National Cancer Institute،Vol. 17, no. 3, pp.184-192.
https://search.emarefa.net/detail/BIM-29830
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Habib, Imad Izzat…[et al.]. Genetic Polymorphism of Folate and Methionine Metabolizing Enzymes and their Susceptibility to Malignant Lymphoma. Journal of the Egyptian National Cancer Institute Vol. 17, no. 3 (Sep. 2005), pp.184-192.
https://search.emarefa.net/detail/BIM-29830
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Habib, Imad Izzat& Aziz, Muna& Qutub, Majd H.. Genetic Polymorphism of Folate and Methionine Metabolizing Enzymes and their Susceptibility to Malignant Lymphoma. Journal of the Egyptian National Cancer Institute. 2005. Vol. 17, no. 3, pp.184-192.
https://search.emarefa.net/detail/BIM-29830
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 190-192
رقم السجل
BIM-29830
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر