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Comparative study of NMP-22, telomerase, and BTA in the detection of bladder cancer
المؤلفون المشاركون
Ibrahim, Ibrahim Khalil
Abd al-Jawad, Manal A.
Musa, Hibah S.
Nasr, Maha I.
al-Gemae, Imad H.
Masud, Amr M.
al-Hifnawi, Nifin M.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 17، العدد 3 (30 سبتمبر/أيلول 2005)، ص ص. 193-202، 10ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2005-09-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Purpose: The diagnostic efficacy of Nuclear Matrix Protein-22 (NMP-22), bladder tumor antigen (BTA TRAK), and telomerase activity was evaluated in urine in a trial to assess their value in the detection of bladder cancer and to compare it to that of routine urine cytology. Subjects and Methods: The study included 46 newly diagnosed bladder cancer patients, diagnosed by cystoscopy and histopathological typing, in addition to 20 patients with benign bladder lesions and 20 healthy age and sex matched volunteers as a control group.
Fifty percent of the cancer patients (23/46) had proven bilharzial history. Most patients (27/46) had transitional cell carcinoma (TCC), 17/46 had squamous cell carcinoma (SCC), while only 2 patients had adenocarcinoma.
A single freshly voided urine sample (? 100ml) was collected from each patient and control subject and aliquoted for each test.
All assays were conducted according to the manufacturer’s guidelines and the results were compared to those of urine cytology. Results: The optimal cutoffs for NMP-22, BTA and telomerase activity as calculated by ROC curves were 12.1 U/ml, 78 U/ml, 0.48 (Ratio) respectively.
The levels of the three parameters were significantly higher in the malignant group compared to either the benign group or normal controls, (p<0.001) and the positive rates were also higher in the malignant group for all 3 parameters. The overall sensitivity of urine cytology, NMP-22, BTA and telomerase was 54.3%, 91.3%, 100% and 80.4% respectively.
For bilharzial cancer bladder respective sensitivities were 69.6%, 95.6%, 100% and 73.9%, while for nonbilharzial cancer bladder the respective sensitivities were 39.1%, 87%, 100% and 87%.
The overall specificities with urine cytology, NMP-22, BTA and telomerase was 100%, 87.5%, 92.5% and 95.0%, respectively.
Combined sensitivity of voided urine cytology with one or more of the 3 biomarkers, or the use of these biomarkers in double or triple combinations gave higher positivity than each biomarker alone.
Conclusion: BTA showed the highest sensitivity in all the studied parameters in the bladder cancer group, bilharzial bladder cancer subgroup, and non bilharzial bladder subgroup, (100%), while the highest specificity was recorded with urine cytology (100%), followed by telomerase (95%), then BTA (92.5%), and lastly NMP- 22 (87.5%).
Use of markers in combination with cytology, or in a panel, improved the sensitivity, and specificity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Jawad, Manal A.& Musa, Hibah S.& Nasr, Maha I.& al-Gemae, Imad H.& Masud, Amr M.& Ibrahim, Ibrahim Khalil…[et al.]. 2005. Comparative study of NMP-22, telomerase, and BTA in the detection of bladder cancer. Journal of the Egyptian National Cancer Institute،Vol. 17, no. 3, pp.193-202.
https://search.emarefa.net/detail/BIM-29831
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Jawad, Manal A.…[et al.]. Comparative study of NMP-22, telomerase, and BTA in the detection of bladder cancer. Journal of the Egyptian National Cancer Institute Vol. 17, no. 3 (Sep. 2005), pp.193-202.
https://search.emarefa.net/detail/BIM-29831
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Jawad, Manal A.& Musa, Hibah S.& Nasr, Maha I.& al-Gemae, Imad H.& Masud, Amr M.& Ibrahim, Ibrahim Khalil…[et al.]. Comparative study of NMP-22, telomerase, and BTA in the detection of bladder cancer. Journal of the Egyptian National Cancer Institute. 2005. Vol. 17, no. 3, pp.193-202.
https://search.emarefa.net/detail/BIM-29831
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 201-202
رقم السجل
BIM-29831
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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