Induction chemotherapy with paclitaxel and cisplatin, followed by concomitant cisplatin and radiotherapy for the treatment of locally advanced nasopharyngeal carcinoma
المؤلفون المشاركون
Mustafa, Ihab
Nassar, Muhammad N.
Rabi, Nabil A.
Ibrahim, Samir A.
Barakat, Hamad M.
Rabi, Amr N.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 18، العدد 4 (31 ديسمبر/كانون الأول 2006)، ص ص. 348-356، 9ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2006-12-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Purpose : To evaluate the efficacy and outcome of neoadjuvant paclitaxel and cisplatin chemotherapy fol-lowed by concurrent cisplatin and irradiation in patients with locally advanced nasopharyngeal (NP) squamous cell carcinoma.
Patients and Methods : The trial included 36 patients with locally advanced nasopharyngeal squamous carcinoma presented to Radiation Oncology and Otolaryngology departments-Ain Shams university hospitals, and Sohag Cancer Center between November 2002 and March 2006.
Eligible patients were treated first with three cycles of induction chemotherapy (IC), paclitaxel (175mg / m2 on day 1) and cisplatin (80mg / m2 on day 1) followed by concomitant conventionally fractionated radiation (70Gy in 2Gy fractions) and cisplatin 20-mg / m2 / day on days 1-5, 22-26 and 43-47 of the radiation therapy.
Results : Twenty nine patients (80 %) and 32 patients (89 %) achieved objective response after IC and concom¬itant chemoradiation (CCRT) respectively.
The actuarial 3 years survival was 68 %, and the actuarial 3 year pro¬gression free survival (PFS) was 66 %.
Survival and PFS were significantly better for patients with smaller tumor volume (stage III), compared with patients with stage I V.
Thirteen patients (36 %) have elements of local and / or regional failure and 5 patients (14 %) have an element of distant metastasis.
Neutropenia (25 %), mucositis (22 %) and vomiting (20 %) were the most severe toxicities re¬corded (grade 3 and 4) during IC while mucositis (36 %), dermatitis (28 %), anemia (14 %) and vomiting (14 %) were the most pronouncing toxicities (grade 3 and 4) during CCRT.
Conclusions : IC followed by CCRT treatment program is feasible, tolerable and safe.
This strategy improved local control and distant disease control.
However com-bined treatment program have failed to improve survival rates over the historical result of CCRT trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mustafa, Ihab& Nassar, Muhammad N.& Rabi, Nabil A.& Ibrahim, Samir A.& Barakat, Hamad M.& Rabi, Amr N.. 2006. Induction chemotherapy with paclitaxel and cisplatin, followed by concomitant cisplatin and radiotherapy for the treatment of locally advanced nasopharyngeal carcinoma. Journal of the Egyptian National Cancer Institute،Vol. 18, no. 4, pp.348-356.
https://search.emarefa.net/detail/BIM-29883
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mustafa, Ihab…[et al.]. Induction chemotherapy with paclitaxel and cisplatin, followed by concomitant cisplatin and radiotherapy for the treatment of locally advanced nasopharyngeal carcinoma. Journal of the Egyptian National Cancer Institute Vol. 18, no. 4 (Dec. 2006), pp.348-356.
https://search.emarefa.net/detail/BIM-29883
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mustafa, Ihab& Nassar, Muhammad N.& Rabi, Nabil A.& Ibrahim, Samir A.& Barakat, Hamad M.& Rabi, Amr N.. Induction chemotherapy with paclitaxel and cisplatin, followed by concomitant cisplatin and radiotherapy for the treatment of locally advanced nasopharyngeal carcinoma. Journal of the Egyptian National Cancer Institute. 2006. Vol. 18, no. 4, pp.348-356.
https://search.emarefa.net/detail/BIM-29883
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p p. 355-356
رقم السجل
BIM-29883
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر