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Pre-irradiation chemotherapy in high risk medulloblastoma
المؤلف
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 18، العدد 4 (31 ديسمبر/كانون الأول 2006)، ص ص. 357-362، 6ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2006-12-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Rationale : The present study evaluates the effect of pre-irradiation chemotherapy in pediatric patients with high risk medulloblastoma.
Twenty-four (24) pediatric patients attended the pediatric unit of Kasr-El-Aini Center of Radiation Oncology and Nuclear Medcine (NEMROCK) from January 2000 to January 2003.
Patients and Methods : Our patients were 13 boys and 11 girls aged 3-12 years with a median of 6.5 years.
According to Chang staging system 6 cases had T2, 14 cases had T3 A and 4 cases had T3 B, 20 cases were M0, 3 cases were M1 and 1 case was M2.
All patients were treated by initial surgery, 2 cycles of pre-irradiation chemotherapy followed by craniospinal radiation then by 4 cycles of post-radiation chemotherapy.
Results : Fifteen out of the 20 patients with M0 had objective response (10CR + 5PR) and no one had disease progression after pre-irradiation chemotherapy.
Among 4 patients with M0 disease, 2 patients had PR and 2 had S.D.
There was no disease progression among patients who received pre-irradiation chemotherapy.
The 3-year overall survival and 3-year progression-free survival ; (PFS) were 50 % and 51 %, respectively, Myelosuppresion was the main toxic effect observed during pre-irradiation chemotherapy ; however, there was no delay or interruption of craniospinal irradiation.
Conclusion : Pre-irradiation chemotherapy is effective in high risk medulloblastoma and is associated with acceptable side effects.
The delay in craniospinal irradiation (CSI) for about 5 weeks to receive 2 courses of chemo¬therapy will not significantly increase disease progression.
Multiple cycles of post-irradiation chemotherapy can be given safely after CSI.
A larger number of patients and longer follow-up is needed to confirm the results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Al, Hisham H.. 2006. Pre-irradiation chemotherapy in high risk medulloblastoma. Journal of the Egyptian National Cancer Institute،Vol. 18, no. 4, pp.357-362.
https://search.emarefa.net/detail/BIM-29900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Al, Hisham H.. Pre-irradiation chemotherapy in high risk medulloblastoma. Journal of the Egyptian National Cancer Institute Vol. 18, no. 4 (Dec. 2006), pp.357-362.
https://search.emarefa.net/detail/BIM-29900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Al, Hisham H.. Pre-irradiation chemotherapy in high risk medulloblastoma. Journal of the Egyptian National Cancer Institute. 2006. Vol. 18, no. 4, pp.357-362.
https://search.emarefa.net/detail/BIM-29900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : pp. 361-362
رقم السجل
BIM-29900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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