Pre-irradiation chemotherapy in high risk medulloblastoma
المؤلف
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 18، العدد 4 (31 ديسمبر/كانون الأول 2006)، ص ص. 357-362، 6ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2006-12-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Rationale : The present study evaluates the effect of pre-irradiation chemotherapy in pediatric patients with high risk medulloblastoma.
Twenty-four (24) pediatric patients attended the pediatric unit of Kasr-El-Aini Center of Radiation Oncology and Nuclear Medcine (NEMROCK) from January 2000 to January 2003.
Patients and Methods : Our patients were 13 boys and 11 girls aged 3-12 years with a median of 6.5 years.
According to Chang staging system 6 cases had T2, 14 cases had T3 A and 4 cases had T3 B, 20 cases were M0, 3 cases were M1 and 1 case was M2.
All patients were treated by initial surgery, 2 cycles of pre-irradiation chemotherapy followed by craniospinal radiation then by 4 cycles of post-radiation chemotherapy.
Results : Fifteen out of the 20 patients with M0 had objective response (10CR + 5PR) and no one had disease progression after pre-irradiation chemotherapy.
Among 4 patients with M0 disease, 2 patients had PR and 2 had S.D.
There was no disease progression among patients who received pre-irradiation chemotherapy.
The 3-year overall survival and 3-year progression-free survival ; (PFS) were 50 % and 51 %, respectively, Myelosuppresion was the main toxic effect observed during pre-irradiation chemotherapy ; however, there was no delay or interruption of craniospinal irradiation.
Conclusion : Pre-irradiation chemotherapy is effective in high risk medulloblastoma and is associated with acceptable side effects.
The delay in craniospinal irradiation (CSI) for about 5 weeks to receive 2 courses of chemo¬therapy will not significantly increase disease progression.
Multiple cycles of post-irradiation chemotherapy can be given safely after CSI.
A larger number of patients and longer follow-up is needed to confirm the results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Al, Hisham H.. 2006. Pre-irradiation chemotherapy in high risk medulloblastoma. Journal of the Egyptian National Cancer Institute،Vol. 18, no. 4, pp.357-362.
https://search.emarefa.net/detail/BIM-29900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Al, Hisham H.. Pre-irradiation chemotherapy in high risk medulloblastoma. Journal of the Egyptian National Cancer Institute Vol. 18, no. 4 (Dec. 2006), pp.357-362.
https://search.emarefa.net/detail/BIM-29900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Al, Hisham H.. Pre-irradiation chemotherapy in high risk medulloblastoma. Journal of the Egyptian National Cancer Institute. 2006. Vol. 18, no. 4, pp.357-362.
https://search.emarefa.net/detail/BIM-29900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : pp. 361-362
رقم السجل
BIM-29900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر