Association between diabetes mellitus type 1 and celiac disease : case-control study among Sudanese patients 2009-2011
المؤلفون المشاركون
Lutfi, Muhammad Faysal
Bolad, Ahmad
Faruq, Ahmad
Nemeiri, Mustafa
المصدر
Sudan Journal of Medical Sciences
العدد
المجلد 7، العدد 2 (31 مارس/آذار 2012)، ص ص. 105-110، 6ص.
الناشر
جامعة أم درمان الإسلامية كلية الطب
تاريخ النشر
2012-03-31
دولة النشر
السودان
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Gluten sensitive enteropathy (celiac disease (CD)) has a strong association with diabetes mellitus (type 1DM).
Since, 2-3% of CD patients have selective IgA deficiency, the majority of the available tests may fail to show the auto-antibodies (the IgA endomysial antibody (EMA).
To prevent such a false negativity, a new Enzyme Linked Immune Sorbent Assay (ELISA) test has been introduced to detect both IgG and IgA antibodies reactive with tissue transglutaminase (tTG), an autoantigen in CD patients.
Objectives: This study has been conducted to detect celiac disease among Sudanese patients with type 1 autoimmune diabetes using anti-tissue transglutinamase antibodies as a diagnostic tool.
Patients and Methods: Samples were collected from sixty nine randomly selected patients (38 males and 31 females) and their age ranged between 3-22 years with DM type 1 who were attending the outpatient clinics in Gabir Abu Eliz diabetic Center and Omdurman Pediatric Emergency Hospital.
Blood samples were collected from 25 healthy individuals as controls.
Levels of tTG specific IgA, tTG specific IgG and anti-endomysial antibodies of IgA class were measured in sera collected from both cases and from controls.
All the results were analyzed using Statistical Packages of Social Sciences (SPSS) version 17 and MicroSoft office excel.
Results: Seven out of 69 patients with DM type 1 (10.1%) were identified as having CD using IgG anti-tTG and 5 (7.2%) of them were positive for IgA anti-tTG and IgA anti-endomysial antibodies.
The mean of both anti-tTG IgA and IgG titers were higher in diabetic patients (M±SD = 12.30±41.0 and 7.2±13.1 respectively) when compared with the control group (M±SD =1.8±1.1 and 1.8±0.9 respectively), however, only anti-tTG IgG antibodies titer achieved statistical significance.
Discussion and conclusion: The present study revealed that patients with DM type I have an increased tendency to develop CD.
The increased association of CD and selective IgA deficiency is a potential source of false-negative IgA, therefore testing for IgG class autoantibodies is recommended if celiac disease is suspected.
Antibodies to tTG antigen fall once a gluten-free diet has begun, thus facilitating monitoring of dietary compliance.
Thus, anti-tTG antibodies are highly sensitive marker for celiac disease with 95- 100 % sensitivty, and specificity of 90 to 97 %.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bolad, Ahmad& Faruq, Ahmad& Lutfi, Muhammad Faysal& Nemeiri, Mustafa. 2012. Association between diabetes mellitus type 1 and celiac disease : case-control study among Sudanese patients 2009-2011. Sudan Journal of Medical Sciences،Vol. 7, no. 2, pp.105-110.
https://search.emarefa.net/detail/BIM-301033
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bolad, Ahmad…[et al.]. Association between diabetes mellitus type 1 and celiac disease : case-control study among Sudanese patients 2009-2011. Sudan Journal of Medical Sciences Vol. 7, no. 2 (Jun. 2012), pp.105-110.
https://search.emarefa.net/detail/BIM-301033
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bolad, Ahmad& Faruq, Ahmad& Lutfi, Muhammad Faysal& Nemeiri, Mustafa. Association between diabetes mellitus type 1 and celiac disease : case-control study among Sudanese patients 2009-2011. Sudan Journal of Medical Sciences. 2012. Vol. 7, no. 2, pp.105-110.
https://search.emarefa.net/detail/BIM-301033
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 110
رقم السجل
BIM-301033
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر