Risk factors of cardiovascular disease among children with chronic kidney disease in Gaza Strip
العناوين الأخرى
عوامل خطر الإصابة بأمراض القلب و الأوعية الدموية بين الأطفال المصابين بمرض الكلى المزمن في قطاع غزة
مقدم أطروحة جامعية
مشرف أطروحة جامعية
Sharif, Fadil A.
Yasin, Majid M.
الجامعة
الجامعة الإسلامية
الكلية
كلية العلوم
القسم الأكاديمي
قسم العلوم الحياتية
دولة الجامعة
فلسطين (قطاع غزة)
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2009
الملخص الإنجليزي
Chronic kidney disease (CKD) is increasingly recognized as a global public health problem.
Cardiovascular disease (CVD) is a major cause of mortality in patients with mild to moderate CKD and end-stage renal disease (ESRD).
There is accumulating evidence that the increase in CVD burden is present in CKD patients prior to dialysis, due to both conventional risk factors as well as those specific to kidney disease.
Detection and initiation of treatment for CVD risk factors at earlier stages of CKD should be effective in reducing CVD events both before and after the onset of kidney failure.
Therefore, this study aimed to assess a group of traditional CVD risk factors including, hypertension, diabetes, dyslipidemia, physical inactivity, body mass index (BMI), family history of CVD, and CKD-specific CVD risk factors including, hypoalbuminemia, albuminuria, anemia, Ca x P product, and inflammation (C-reactive protein), in CKD patients in Gaza strip, aged ≤ 12 years old and haven't undergone kidney replacement therapy.
Patients of the study (40 male and 20 female) were categorized into 4 stages (2, 3, 4, and 5) where stage 1 was not encountered.
Stage 4 had the highest distribution, followed by stage 3, stage 5 and stage 2.
There were statistically significant differences between patients and controls in the terms of height, weight, systolic blood pressure (SBP), and diastolic blood pressure (DBP), where the mean values indicated that the patients were shorter, had lower weight, higher SBP and DBP with 47 % of the patients having hypertension.
Frequency of physical inactivity among patients was 2-fold higher as compared to controls (50 % vs.
25 %).
As compared to controls, patients had significantly higher means of cholesterol (163.6 ± 39.8 vs.
141.8 ± 24.2 mg / dl, p = 0.001), triglycerides (145.5 ± 67.1 vs.
82.9 ± 39.8 mg / dl, p = 0.000), Low density lipoprotein (LDL) (92.6 ± 31.9 vs.
72.5 ± 19 mg / dl, p = 0.000), and they had lower means of high density lipoprotein (HDL) (41.9 ± 11.0) vs.
52.7 ± 11.7 mg / dl, p = 0.000).
As compared to controls, patients had significantly lower hemoglobin (9.8 ±1.4 vs.
11.9 ± 0.8 g / dl, p = 0.000), albumin (0.6 ± 4.6 vs.
4.8 ± 0.2 g / dl, p = 0.012) and higher albumin / creatinine ratio (ACR) (3183 ± 1792vs.
11.1 ± 6.6 mg / g, p = 0.000).
C- reactive protein (CRP) showed high occurrence among patients (40 % were positive for CRP).
Calcium and phosphorus evaluation showed significantly lower calcium and higher phosphorus among patients.
However, Ca X P product was not statistically significant in patients compared to controls (52.4 vs.
53.4 mg2 / dl2, p = 0.582).
This study indicates that many of the CVD risk factors are associated with different stages of CKD in children patients prior to dialysis, and that these factors are exacerbated as CKD progresses.
التخصصات الرئيسية
الموضوعات
عدد الصفحات
78
قائمة المحتويات
Table of contents.
Abstract.
Chapter one : Introduction.
Chapter two : Literature review.
Chapter three : Materials and methods.
Chapter four : Results.
Chapter five : Discussion.
Chapter six : Conclusion and recommendations.
References.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhaysin, Rafat Muhammad. (2009). Risk factors of cardiovascular disease among children with chronic kidney disease in Gaza Strip. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-303472
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhaysin, Rafat Muhammad. Risk factors of cardiovascular disease among children with chronic kidney disease in Gaza Strip. (Master's theses Theses and Dissertations Master). Islamic University. (2009).
https://search.emarefa.net/detail/BIM-303472
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhaysin, Rafat Muhammad. (2009). Risk factors of cardiovascular disease among children with chronic kidney disease in Gaza Strip. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-303472
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-303472
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر