Some biochemical changes associated with taking oral contraceptive pills among healthy women in Gaza City
العناوين الأخرى
بعض التغيرات البيوكيميائية للنساء الأصحاء اللواتي يتناولن حبوب منع الحمل في مدينة غزة
مقدم أطروحة جامعية
Abu Hani, Islah Muhammad Diyab
مشرف أطروحة جامعية
الجامعة
الجامعة الإسلامية
الكلية
كلية العلوم
القسم الأكاديمي
قسم العلوم الحياتية
دولة الجامعة
فلسطين (قطاع غزة)
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2010
الملخص الإنجليزي
Aim : to evaluate some biochemical changes associated with oral contraceptive (OC) pills administration on healthy women in Gaza City (GC).
Methodology : the study design was a case control.
The sample size was 80 healthy women aged 20-35 years from the Swidey Clinic who had taken OC pills for at least three continuous cycles.
The control sample was healthy married women who were not going on OC before and match the cases in age and residence.
The study questionnaire included issues about the following information : age, gender, weight, height, health history, blood pressure, Nature of menstrual cycle, bleeding, insomnia, pain in the stomach, difficulty in breath, pain in hands and feet, appetite and headaches.
Blood parameters analysis of the study population included complete blood count (CBC), C-reactive protein (CRP), high density lipoproteins cholesterol (HDL-C), low density lipoproteins cholesterol (LDL-C), total cholesterol (TC), and triacylglycerol) (TAG).
Leptin determination was carried out using a commercially available diagnostic system test kits.
SPSS were used to analyze obtained data.
Results : the results showed statistically significant differences among study population with respect to regular of menstrual cycle (MC) (Χ2 =5.371, P = 0.024), increased appetite (Χ2 = 4.386, P = 0.002), increased headache (Χ2 = 6.82, P = 0.000), increased body mass index (Χ2 = 7.31, P = 0.015), cholesterol were significantly higher among the cases compared to control (179.1 ± 4.3mg / dl vs 157.5 ± 4.12mg / dl, and p = 0.000), LDLC were significantly higher among the cases compared to control (97.6 ± 3.8mg / dl vs 86.2 ± 3.4 mg / dl, and p=0.002), increased C-reactive protein (Χ 2 = 5.381, p = 0.034), there were a significant increase in the mean level of leptin among the cases compared to the controls (36.3 ± 2.3 ng / ml vs.
28.6 ± 2.1 ng / ml, and p = 0.003), and the levels of WBC, Gran and Mch were significantly higher among the cases (7.2 ± 2.1 K / µL, 60.7 ± 8.3 % and 26.9 ± 2.2pg) compared to the controls (6.6 ± 1.7 K / µL, 54.9 ± 11.7 % and 25.7 ± 3.4 pg), with p=0.001, p=0.000 and p=0.003, respectively.
In contrast, the results showed no statistically significant differences among the study population with respect to frequency of bleeding (Χ2 = 0.192, P = 0.135), frequency of insomnia (Χ2 = 0.411, P = 0.353), pain in stomach (Χ2 = 0.386, P = 0.183), difficulty in breathing (Χ2=0.497, P = 0.209), frequency of pain in hands and feet (Χ2 = 0.631, P = 0.309), Systolic blood pressure (Χ2 = 2.351, P=0.139), diastolic blood pressure (Χ2 = 1.372, P=0.382), HDL-c (51.2 ± 1.7 mg / dl vs 47.6 ± 1.3mg / dl and p = 0.148), TAG (119.2 ± 6.0mg / dl vs 108.2 ± 8.6 mg / dl and p = 0.218), the changes among the study population in Mid, RBc, Hb, Hct, Mcv, Mchc and PLt (7.8 ± 8.7 %, 4.6 ± 0.7M / µL,12.2 ± 0.9g / dl, 38.0 ± 2.4 %, 80.8 ± 11.9fl 32.5 ± 1.1 g / dl and 279.3 ± 87.6K / µL) compared to control were not significant (8.6 ± 6.6, 4.6 ± 0.4 M / µL, 12.3 ± 1.1g / dl, 37.5 ± 3.7 %, 80.6 ± 8.5fl, 32.3 ± 1.7g / dl and 267.8 ± 74.0 K / µL), with p = 0.352, p = 0.394, p = 0.387, p = 0.571, p = 0.415, p = 0.272 and p = 0.185, respectively.
Moreover, the results showed strong correlation between BMI and leptin (p = 0.000) among the study population.
Methodology: The study design was a case control.
The sample size was 80 healthy women aged 20-35 years from the Swidey Clinic who had taken OC pills for at least three continuous cycles.
The control sample was healthy married women who were not going on OC before and match the cases in age and residence.
The study questionnaire included issues about the following information: age, gender, weight, height, health history, blood pressure, Nature of menstrual cycle, bleeding, insomnia, pain in the stomach, difficulty in breath, pain in hands and feet, appetite and headaches.
Blood parameters analysis of the study population included complete blood count (CBC), C-reactive protein (CRP), high density lipoproteins cholesterol (HDL-C), low density lipoproteins cholesterol (LDL-C), total cholesterol (TC), and triacylglycerol (TAG).
Leptin determination was carried out using a commercially available diagnostic system test kits.
SPSS were used to analyze obtained data.
Results: The results showed statistically significant differences among study population with respect to regular of menstrual cycle (MC) (2=5.371, P= 0.024), increased appetite (2= 4.386, P= 0.002), increased headache (2= 6.82, P= 0.000), increased body mass index (2= 7.31, P= 0.015), cholesterol were significantly higher among the cases compared to control (179.1± 4.3mg/dl vs 157.5± 4.12mg/dl, and p=0.000), LDLC were significantly higher among the cases compared to control (97.6±3.8mg/dl vs 86.2± 3.4 mg/dl, and p=0.002), increased C-reactive protein (2= 5.381, p= 0.034), there were a significant increase in the mean level of leptin among the cases compared to the controls (36.3± 2.3 ng/ml vs.
28.6± 2.1 ng/ml, and p= 0.003), and the levels of WBC, Gran and Mch were significantly higher among the cases (7.2±2.1 K/µL, 60.7±8.3 % and 26.9±2.2pg) compared to the controls (6.6±1.7 K/µL, 54.9±11.7 % and 25.7±3.4 pg), with p=0.001, p=0.000 and p=0.003, respectively.
In contrast, the results v showed no statistically significant differences among the study population with respect to frequency of bleeding (2=0.192, P=0.135), frequency of insomnia (2=0.411, P=0.353), pain in stomach (2=0.386, P=0.183), difficulty in breathing(2=0.497, P= 0.209), frequency of pain in hands and feet (2=0.631, P= 0.309), Systolic blood pressure ((2=2.351, P=0.139 ), diastolic blood pressure (2=1.372, P=0.382 ), HDL-c (51.2±1.7mg/dl vs 47.6±1.3mg/dl and p=0.148), TAG (119.2± 6.0mg/dl vs 108.2± 8.6 mg/dl and p=0.218), the changes among the study population in Mid, RBc, Hb, Hct, Mcv, Mchc and PLt (7.8±8.7 %, 4.6±0.7M/µL,12.2±0.9g/dl, 38.0±2.4%, 80.8±11.9fl, 32.5±1.1g/dl and 279.3±87.6K/µL) compared to control were not significant (8.6±6.6 %, 4.6±0.47M/µL, 12.3±1.1g/dl, 37.5±3.7%, 80.6±8.5fl, 32.3±1.7g/dl and 267.8±74.0 K/µL), with p=0.352, p=0.394, p=0.387, p=0.571, p=0.415, p=0.272 and p=0.185, respectively.
Moreover, the results showed strong correlation between BMI and leptin (p= 0.000) among the study population.
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الموضوعات
عدد الصفحات
54
قائمة المحتويات
Abstract.
Table of contents.
Chapter one : Introduction.
Chapter two : Literature review.
Chapter three : Materials and methods.
Chapter four : Results.
Chapter five : Discussion.
Chapter six : Conclusion and recommendations.
References.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abu Hani, Islah Muhammad Diyab. (2010). Some biochemical changes associated with taking oral contraceptive pills among healthy women in Gaza City. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-303490
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abu Hani, Islah Muhammad Diyab. Some biochemical changes associated with taking oral contraceptive pills among healthy women in Gaza City. (Master's theses Theses and Dissertations Master). Islamic University. (2010).
https://search.emarefa.net/detail/BIM-303490
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abu Hani, Islah Muhammad Diyab. (2010). Some biochemical changes associated with taking oral contraceptive pills among healthy women in Gaza City. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-303490
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-303490
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر