Helicobacter pylori, a potential causative agent of vitamin b12 deficiency

العناوين الأخرى

إمكانية نقص فيتامين ب 12 الناتجه عن الإصابه بالبكتريا الحلزونيه

مقدم أطروحة جامعية

Sarari, Abd al-Salam Ali

مشرف أطروحة جامعية

Hammudah, Wail
Isawi, Tamir
Farraj, Muhammad A.

أعضاء اللجنة

Abu Sadah, Gabi
Abu Safiyyah, Yasir

الجامعة

جامعة بيرزيت

الكلية

كلية العلوم

القسم الأكاديمي

دائرة الأحياء و الكيمياء الحيوية

دولة الجامعة

فلسطين (الضفة الغربية)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2006

الملخص الإنجليزي

Helicobacter pylori are considered to be the most common human pathogen colonizing the gastric mucosa of almost all people worldwide.

It has been implicated in increasing the risk of developing gastric cancer which is the second most frequent cause of cancer-related deaths.

The prevalence of Helicobacter pylori in the developing countries is 70 to 90 % as compared to 20 to 50 % in developed countries.

The infection is believed to be acquired during childhood.

Vitamin B12 or cobalamin deficiency occurs frequently (> 20 %) among elderly people.

Causes of the deficiency include food cobalamin malabsorption syndrome (> 60 % of all cases), pernicious anemia (15 %–20 % of all cases), insufficient dietary intake and malabsorption.

Helicobacter pylori have been implicated as the potential causative agent of vitamin B12 deficiency and pernicious anemia.

Gastritis caused by Helicobacter pylori leads to destruction of parietal cells Helicobacter pylori producing the intrinsic factor needed for vitamin B12 absorption.

It is well established that eradication of H.

pylori led to improved blood levels of vitamin B12 in 40 % of the cases.

The aim of this study was to evaluate the association between vitamin B12 deficiency, and Helicobacter pylori infection.

In addition we compared invasive and noninvasive methods routinely used to diagnose Helicobacter pylori infection.

Our finding indicates that Helicobacter pylori infection was detected in 71.66 % of those patients tested.

Vitamin B12 deficiency was evident in 72.1 % of those cases.

These result correlated well with elevated mean cell volume (MCV) 62.8 %.

Smoking as well as gender does not seem to increase the risk of developing of vitamin B12 deficiency.

Our results indicate that Helicobacter pylori are implicated as a causative agent in the development of adult vitamin B12 deficiency in adult.

التخصصات الرئيسية

الطب البشري

عدد الصفحات

77

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-303592