Plasma total homocysteine and risk of coronary atherosclerosis in Palestine

العناوين الأخرى

الهوموسيستين الكلي في البلزما و خطورة الصابة بتصلب الشرايين التاجية في فلسطين

مقدم أطروحة جامعية

Najjar, Usamah Ahmad

مشرف أطروحة جامعية

Khatib, Samir
Batrawi, Muhammad

أعضاء اللجنة

Khayri, Lina
Amin, Riyad

الجامعة

جامعة بيرزيت

الكلية

كلية العلوم

القسم الأكاديمي

دائرة الأحياء و الكيمياء الحيوية

دولة الجامعة

فلسطين (الضفة الغربية)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2007

الملخص الإنجليزي

Many researchers have shown that elevated total plasma Homocysteine has a significant association with coronary heart diseases, cardiovascular diseases and other cardiac diseases. In this present case control study, I investigated whether fasting total Homocysteine has a strong association with coronary artery diseases.

Also, correlation between fasting t-Hcy and severity of atherosclerosis was studied.

Furthermore, levels of cholesterol, triglycerides, HDL, LDL, and uric acid, were studied as conventional risk factors of atherosclerosis to compare them with total Homocysteine.

Subjects were recruited from men and women, aged 21 to 85 years, who underwent coronary angiography (cardiac catheterization) between March 2004 and August 2004 at Ramallah Hospital catheterization laboratory.

Cases (n = 189) where defined as those with ≥ 50 % occlusion of any coronary artery, while control subjects (n = 103) had < 50 % occlusion in any coronary artery or had no occlusion at all.

In addition a population-based control group free from clinical cardiovascular disease (n = 96) was studied. Cases had 31.2 % higher mean fasting total homocysteine than both control groups (P=0.00).

While between the two control groups the mean total plasma homocysteine is almost the same, and there is no statistical difference between their means (P = 0.147).

The odds ratios (OR) for coronary atherosclerosis and hyperhomocysteinemia was 3.27 (95 % CI, 2.14– 4.99) using Hcy cutoff value 14.7 (Established cutoff value from this study) and before adjusting for age, sex and other confounders.

But after adjusting for age, sex and other confounders OR was 3.12(95 % CI, 1.95–4.99).

Furthermore, increasing fasting total homocysteine was associated with severity of atherosclerosis measured as increasing number of occluded arteries (P = 0.00).

For the other conventional risk factors HDL, cholesterol, and triglycerides were statistically insignificant as risk factors for coronary atherosclerosis and their significance was (P = 0.383, P = 0.077, and P = 0.507 respectively).

While for Uric acid and LDL they were statistically significant (P = 0.011 and P = 0.00 respectively). In conclusion, the main finding in this population group is that plasma total Homocysteine is strongly related to coronary atherosclerosis and to its severity.

These results should encourage further studies of tHcy as a prognostic marker or risk factor for coronary atherosclerosis in Palestine.

التخصصات الرئيسية

الطب البشري

الموضوعات

• الأمراض
• فلسطين

عدد الصفحات

128

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-303655