Protection from the acute cisplatin-induced nephrotoxicity by simvastatin in rats

الملخص EN

Background : the usefulness of cis-platin, a potent anti-tumor, is limited by its ability to induce nephrotoxicity.

The cellular changes leading to this toxicity are suggested to be mediated by increased free radicals generation and lipid peroxidation.

Aim of the study: To investigate the protective properties of simvastatin on cis-platin-induced nephrotoxicity in rats using biochemical and histopatho- theological approaches.

Material and methods: 35 healthy male Swiss albino rats were used.

They were divided into 5 groups (7 animals in each group and all animals supplied with standard food during the experiment) : control group (1 ml / kg of normal saline i.p.

once daily for 14 days), cis-platin treated group (7.5 mg / kg, i.p.

single dose), simvastatin treated group (1 mg / kg, i.p., once daily for 14 days), simvastatin (1 mg / kg) plus cis-platin treated group (i.p., once daily for 7 days before and after cis-platin injection), and simvastatin (2 mg / kg) plus cis-platin treated group (i.p., once daily for 7 days before and after cis-platin injection).

Blood samples were collected and used to determine the serum urea, creatinine and total antioxidant status (TAS) levels.

Kidneys were removed and prepared for histopathologically examinations.

Results: In simvastatin plus cis-platin treated groups serum urea and creatinine were significantly lower than those of cis-platin-treated group, While serum TAS was increase.

These changes occurred in a dose-dependent manner (simvastatin).

Histopathologically examinations showed a massive damage in the proximal tubules in cis-platin-treated group.

No damage was observed in simvastatin treated groups.

Conclusion : these data show that simvastatin can provide a protective effect against Acute cis-platin-induced nephrotoxicity.

This protective effect of simvastatin may be related to the antioxidant status on the kidney.