Effect of weight reduction drug chitocal contained gymnema sylvester extract on body weight, lipid profiles, kidney function and histological structure of kidney and intestine in male albino rats

الملخص EN

Objective : the objective of this study was to investigate the effect of doses of Critical for 4 weeks on body weight, lipid profiles, kidney functions and histological structure of kidney and intestine in male rats.

Methods : Twenty adult male albino rats (200 -215 gm) were divided into 2 groups: The first group was considered as control group.

The second group was treated orally with Critical (50 mg / kg b.w) by use of intragastric tube.

Different physiological parameters were performed including recording of the body weight and measuring lipid profiles, creatinine and urea levels.

Results : body weight gain, total cholesterol, triglyceride, LDL cholesterol, and VLDL cholesterol levels were significantly (p < 0.05) reduced in Critical treated rats when compared with the control rats.

HDL cholesterol and urea levels were significantly (p < 0.05) increased in Critical treated rats, but creatinine level was none significantly (P < 0.05) increased when compared with the control rats.

Histological examination of Critical treated rats kidney’s showed congestion of blood vessels between renal tubules, aggregation of inflammatory cells in lumen and wall of blood vessels, enlargement of renal tubules and aggregation of inflammatory cells around glomerulus.

In intestine tissue of Critical treated rats moderate increase of monocytes in lamina proporia and hyperplasia of goblet cells was observed, aggregation of inflammatory cells in epithelium, adhesion of intestinal villi, hyperplasia in epithelium and aggregation of inflammatory cells in lamina proporia.

Conclusion: From the results of this study it can be conclude that the treatment with Critical produced a significant reduction in body weight and lipid profiles, but it is incapable of improving the kidney functions.

Also there are histopathologically effects on kidney and intestine tissues in treated rats.