Protective effects of latex of Ficus Carica L. against lead acetate-induced hepatotoxicity in rats
المؤلف
المصدر
Jordan Journal of Biological Sciences
العدد
المجلد 5، العدد 3 (30 سبتمبر/أيلول 2012)، ص ص. 175-181، 7ص.
الناشر
الجامعة الهاشمية عمادة البحث العلمي و الدراسات العليا
تاريخ النشر
2012-09-30
دولة النشر
الأردن
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Ficus carica L.
latex is used traditionally for many therapeutic purposes.
Oxidative stress may be the main reason behind most histological and cellular effects of lead.
The aim of this study was to investigate the possible hepatoprotective role of Ficus carica L .latex against lead acetate-induced oxidative stress in rats.
In the present investigation, lead acetate (500 mg Pb / L) was given orally to male rats for 28 days to induce hepatotoxicity.
The Ficus latex was found to contain high total phenols and flavonoids.
The levels of hepatic markers such as alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) were significantly (P > 0.05)¬ increased in blood serum following lead acetate administration.
Lead-induced oxidative stress in liver tissue was indicated by a significant (P > 0.05)¬ increase in the level of liver Malondialdehyde (MDA) and decreased levels of liver reduced glutathione (GSH) and superoxide dismutase (SOD). Histologically and ultrastructurally, the liver showed several histological alterations such as degeneration of hepatocytes by necrosis and apoptosis, fatty changes and inflammatory cells infiltration.
Ficus latex (1mL of 1 : 50 diluted latex / kg b.
wt) markedly attenuated the previous lead-induced biochemical alterations in serum and liver tissues (P¬ > 0.05) as well as the histological and cellular changes.
From this study, it can be concluded that the Ficus latex showed effective hepatoprotective and antioxidative action against lead acetate-induced hepatotoxicity in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aziz, Falah M.. 2012. Protective effects of latex of Ficus Carica L. against lead acetate-induced hepatotoxicity in rats. Jordan Journal of Biological Sciences،Vol. 5, no. 3, pp.175-181.
https://search.emarefa.net/detail/BIM-311172
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aziz, Falah M.. Protective effects of latex of Ficus Carica L. against lead acetate-induced hepatotoxicity in rats. Jordan Journal of Biological Sciences Vol. 5, no. 3 (Sep. 2012), pp.175-181.
https://search.emarefa.net/detail/BIM-311172
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aziz, Falah M.. Protective effects of latex of Ficus Carica L. against lead acetate-induced hepatotoxicity in rats. Jordan Journal of Biological Sciences. 2012. Vol. 5, no. 3, pp.175-181.
https://search.emarefa.net/detail/BIM-311172
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 179-181
رقم السجل
BIM-311172
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر