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Stability indicating high performance liquid chromatographic (HPLC-DAD) determination of trandolapril in bulk drug and formulation
مقدم أطروحة جامعية
مشرف أطروحة جامعية
Salim, Mahir L.
Shakya, Ashok Kumar
الجامعة
جامعة عمان الأهلية
الكلية
كلية الصيدلة و العلوم الطبية
القسم الأكاديمي
قسم العلوم الصيدلانية
دولة الجامعة
الأردن
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2012
الملخص الإنجليزي
The purpose of this study was to develop a new stability indicating method for the analysis of trandolapril in formulation and raw material.
In the present study a rapid, simple, economical reverse phase HPLC-DAD procedure has been developed for the determination of trandolapril.
The trandolapril was separated isocratic ally on Hypersil-Gold C18 column (Length-250 mm, Diameter- 4.6 mm, Particle size- 5 urn) with a mobile phase consisting of 50 % acetonitrile, 50 % water (containing 0.25 ml / L triethylamine, final pH was adjusted to 3.0 ± 0.1), operated at 25 ± 1 °C with a retention time less than 6 min.
The total run time of the stressed study was 20 mins.
The eluted drug was identified and monitored on a Photo Diode- Array detector (PDA) at 210 nm.
The linearity of the method was excellent (r > 0.9999) over the concentration range of I-24 ug / ml : the LOD and LOQ were 0.0566 ug / ml and 0.1715 ug / ml respectively.
The statistical evaluation of the method was examined by performing intraday and interday precision analysis.
The overall precision (CV.
RSD) was less than 2 %.
Mean recovery of trandolapril was more than 99 %, no interference was found from the other ingredient or component present in the preparation.
The result of stability studies indicates that the drug was stable when exposed to direct sunlight or UV light.
The drug gives 6 different oxidative products on exposure to hydrogen peroxide (oxidative stress).
Under alkaline condition it was converted to trandolaprilate and other derivative products.
Slight degradation (less than 0.4 %) was observed in acidic conditionIn conclusion the method presented here is sensitive, rapid, accurate, precise, economic, robust, rugged and selective for the routine analysis of the drug in formulation and raw material.
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الموضوعات
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hawwash, Lina A.. (2012). Stability indicating high performance liquid chromatographic (HPLC-DAD) determination of trandolapril in bulk drug and formulation. (Master's theses Theses and Dissertations Master). Al-Ahliyya Amman University, Jordan
https://search.emarefa.net/detail/BIM-311671
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hawwash, Lina A.. Stability indicating high performance liquid chromatographic (HPLC-DAD) determination of trandolapril in bulk drug and formulation. (Master's theses Theses and Dissertations Master). Al-Ahliyya Amman University. (2012).
https://search.emarefa.net/detail/BIM-311671
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hawwash, Lina A.. (2012). Stability indicating high performance liquid chromatographic (HPLC-DAD) determination of trandolapril in bulk drug and formulation. (Master's theses Theses and Dissertations Master). Al-Ahliyya Amman University, Jordan
https://search.emarefa.net/detail/BIM-311671
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-311671
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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