Effect of exercise on diabetes-induced oxidative stress in the rat hippocampus
المؤلفون المشاركون
Alipour, M.
Salihi, I.
Soufi, F. Ghadiri
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 14، العدد 4 (30 إبريل/نيسان 2012)، ص ص. 222-228، 7ص.
الناشر
تاريخ النشر
2012-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Oxidative stress forms the foundation for the induction of multiple cellular pathways which can lead to the complications of diabetes mellitus that the most debilitating ones are diseases of the nervous system.
In this study, we evaluated whether treadmill running could alleviate oxidative stress and apoptosis rate in the hippocampus of streptozotocin- induced diabetic rats.
Methods: Forty male Wistar rats were randomly divided into four groups (n=10): Control group (CR), exercised group (CE), diabetic group (DR) and diabetic-exercised group (DE).
Diabetes was induced by injection of streptozotocin in male rats.
All rats in the trained group run on a rodent motor-driven treadmill for eight weeks.
At the end of eight weeks, hippocampi of animals were immediately removed on ice and kept frozen.
The light supernatant was taken and stored at -80°C.
They were used for determination of antioxidant enzymes and TBARs level.
Index of apoptosis was detected by cell death detection ELISA Kit.
Results: Levels of TBARs in DR and DE groups were significantly higher than CR group.
SOD and GPx activities significantly increased in CE group and decreased in DR group.
CAT activity significantly decreased in DR group versus CR group.
The apoptosis rate significantly increased and decreased in DR and CE groups respectively compared to CR.
Conclusion: Exercise had beneficial effects in the diabetic exercised rats, possibly in part because of alterations in the ability to adapt to exercise- induced oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alipour, M.& Salihi, I.& Soufi, F. Ghadiri. 2012. Effect of exercise on diabetes-induced oxidative stress in the rat hippocampus. Iranian Red Crescent Medical Journal،Vol. 14, no. 4, pp.222-228.
https://search.emarefa.net/detail/BIM-311723
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alipour, M.…[et al.]. Effect of exercise on diabetes-induced oxidative stress in the rat hippocampus. Iranian Red Crescent Medical Journal Vol. 14, no. 4 (Apr. 2012), pp.222-228.
https://search.emarefa.net/detail/BIM-311723
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alipour, M.& Salihi, I.& Soufi, F. Ghadiri. Effect of exercise on diabetes-induced oxidative stress in the rat hippocampus. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 4, pp.222-228.
https://search.emarefa.net/detail/BIM-311723
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 227-228
رقم السجل
BIM-311723
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر