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Mitochondrial modulation as a potential mechanism of vetiveria zizanioides root extract against liver damage in mice
المؤلفون المشاركون
Parmar, Mihir Y.
Shah, Purvi A.
Gao, Jing
Gandhi, Tejal R.
المصدر
The Egyptian Journal of Biochemistry and Molecular Biology
العدد
المجلد 29، العدد 1 (30 يونيو/حزيران 2011)، ص ص. 17-30، 14ص.
الناشر
الجمعية المصرية للكيمياء الحيوية و البيولوجيا الجزيئية
تاريخ النشر
2011-06-30
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
The relationship between the expression of mitochondrial voltage dependent anion channels and the protective effects of methanolic extract of Vetiveria zizanioides Linn.
Root against carbon tetrachloride-induced liver damage was investigated.
Pretreatment of mice with Vetiveria zizanioides Linn.
Root extract (300 and 500 mg / kg) significantly blocked the carbon tetrachloride-induced increase in both serum aspartate aminotransferase and serum alanine aminotransferase levels.
The mitochondrial membrane potential was dropped from –188.0 ± 2.5 mV to 3.0 ± 156.8 - mV (P < 0.01) after the mice had been treated with carbon tetrachloride.
Pretreatment with methanolic extract of Vetiveria zizanioides Linn.
Root (300 and 500 mg / kg) attenuated carbon tetrachloride –induced mitochondrial membrane potential dissipation (P > 0.05).
In addition, pretreatment of Vetiveria zizanioides Linn.
Root extract at various concentrations exerted a dose-dependent effect against sensitivity to mitochondrial swelling induced by Calcium.
Also, 500 mg / kg dose of extract significantly increased both transcription and translation of voltage-dependent anion channels, which was down regulated by carbon tetrachloride treatment.
The above data suggest that Vetiveria zizanioides Linn.
Root extract mitigates the damage to liver mitochondria induced by carbon tetrachloride, possibly through the regulation of mitochondrial voltage-dependent anion channels, one of the most important proteins in the mitochondrial outer membrane.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Parmar, Mihir Y.& Shah, Purvi A.& Gao, Jing& Gandhi, Tejal R.. 2011. Mitochondrial modulation as a potential mechanism of vetiveria zizanioides root extract against liver damage in mice. The Egyptian Journal of Biochemistry and Molecular Biology،Vol. 29, no. 1, pp.17-30.
https://search.emarefa.net/detail/BIM-312377
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Parmar, Mihir Y.…[et al.]. Mitochondrial modulation as a potential mechanism of vetiveria zizanioides root extract against liver damage in mice. The Egyptian Journal of Biochemistry and Molecular Biology Vol. 29, no. 1 (Jun. 2011), pp.17-30.
https://search.emarefa.net/detail/BIM-312377
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Parmar, Mihir Y.& Shah, Purvi A.& Gao, Jing& Gandhi, Tejal R.. Mitochondrial modulation as a potential mechanism of vetiveria zizanioides root extract against liver damage in mice. The Egyptian Journal of Biochemistry and Molecular Biology. 2011. Vol. 29, no. 1, pp.17-30.
https://search.emarefa.net/detail/BIM-312377
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 28-30
رقم السجل
BIM-312377
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