Importance of serum levels of angiopoietin-2 and survivin biomarkers in non-small cell lung cancer
المؤلفون المشاركون
Fawzi, Amal
Jafar, Rabab
Qasim, Fatima
Ali, Shawqi S.
al-Shafii, Mustafa
al-Dib, Mahmud
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 24، العدد 1 (31 مارس/آذار 2012)، ص ص. 41-45، 5ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2012-03-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : angiogenesis is an essential process in cancer growth maintenance, and metastasis.
Angiopoietin-2 promotes tumor angiogenesis by priming the vasculature and potentiating the effects of cytokines at the front of active neovascularization.
Enhanced expression of angiopoietin-2 has been reported in lung cancer tissue.
Surviving is one of the inhibitors of apoptosis protein that has been shown to play a key role in cancer progression, and in tumor angiogenesis.
Also plays a key role in tumor cell resistance to anticancer agents and ionizing radiation.
Aim : to measure the serum levels of angiopoietin-2 and surviving as possible antigenic factors in lung cancer patients with the assessment of their interrelationships and clinical significance.
Patients and methods: Patients with lung cancer as NSCLC (n= 70) and healthy volunteers (n= 10) were enrolled.
Serum angiopoietin-2 and surviving concentrations were measured using enzyme-linked immunosorbent assay (ELIZA).
Results : Median serum angiopoietin-2 levels with lung cancer (2730 pg / mL) ranged from 1171 to 6541 pg / mL was higher than the median of the control group (1795 pg / mL) ranged from 1076 to 2730 / mL, p< 0.001.
Median serum surviving levels were also higher in patients with lung cancer (35.0 pg / mL) ranged from 39.3 to 96.3 pg / mL than the median of the control group (48.8 pg / mL) ranged from 38.0 to 74.6 pg / mL, but did not reach statistical significance p = 0.206.
In all patients with lung cancer, serum angiopoietin-2 was not significantly correlated with surviving (r = 0.073, p = 0.657).
Neither serum angiopoietin-2 nor surviving showed significant relation with the serum angiopoietin-2 or surviving levels depending on the cell types, stage progression, and metastasis among the patients with NSCLC.
Conclusions : our study suggests that serum angiopoietin-2 is a useful marker for the diagnosis of NSCLC by ELIZA technique.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fawzi, Amal& Jafar, Rabab& Qasim, Fatima& Ali, Shawqi S.& al-Shafii, Mustafa& al-Dib, Mahmud. 2012. Importance of serum levels of angiopoietin-2 and survivin biomarkers in non-small cell lung cancer. Journal of the Egyptian National Cancer Institute،Vol. 24, no. 1, pp.41-45.
https://search.emarefa.net/detail/BIM-312833
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fawzi, Amal…[et al.]. Importance of serum levels of angiopoietin-2 and survivin biomarkers in non-small cell lung cancer. Journal of the Egyptian National Cancer Institute Vol. 24, no. 1 (Mar. 2012), pp.41-45.
https://search.emarefa.net/detail/BIM-312833
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fawzi, Amal& Jafar, Rabab& Qasim, Fatima& Ali, Shawqi S.& al-Shafii, Mustafa& al-Dib, Mahmud. Importance of serum levels of angiopoietin-2 and survivin biomarkers in non-small cell lung cancer. Journal of the Egyptian National Cancer Institute. 2012. Vol. 24, no. 1, pp.41-45.
https://search.emarefa.net/detail/BIM-312833
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 45
رقم السجل
BIM-312833
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر