Glutathione S-transferase M1 and T1, CYP1A2-2467T delT polymorphisms and non small-cell lung cancer risk in Tunisian sample
المؤلفون المشاركون
Bashir, Fatimah
Aida, Taieb
Maurice, J. Arnaud
Saguem, Sad
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 13، العدد 3 (31 ديسمبر/كانون الأول 2012)، ص ص. 307-312، 6ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2012-12-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
The present study investigated the impact of metabolic gene polymorphisms in modulating lung cancer risk susceptibility.
Gene polymorphisms encoding Cytochrome 1A2 (CYP1A2) and Glutathione-S-transferases (GSTT1 and GSTM1) are involved in the bio activation and detoxification of tobacco carcinogens and may therefore affect lung cancer risk.
In order to assess association between lung cancer and GSTT1, GSTM1 and CYP1A2-2467T / delT, variant allele (CYP1A2*1D) polymorphisms, a case–control study of healthy and smoking lung cancer patients in Tunisian population was conducted.
Polymorphisms of GSTs were assayed by multiplex PCR.
Genotype polymorphism of CYP1A2*1D was determined by PCR-RFLP assay.
Odds Ratio was used for analyzing results.
There was no association with any increase of lung cancer risk in GSTT1 null genotype [OR : 0.83] (0.47-1.45) as well as in GSTM1 null genotype [OR: 0.78 (0.37–1.62)].
However, a significant association between lung cancer and the homozygous mutate variant of the CYP1A2 [(OR = 4.7 (1.55-29.78)] was observed.
These results demonstrated that the strong and significant association between CYP1A2*1D and lung cancer appears to be relevant in this Tunisian population, suggesting that CYP1A2 metabolic genetic factor may, in partly, play a role in modulating lung cancer susceptibility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bashir, Fatimah& Aida, Taieb& Maurice, J. Arnaud& Saguem, Sad. 2012. Glutathione S-transferase M1 and T1, CYP1A2-2467T delT polymorphisms and non small-cell lung cancer risk in Tunisian sample. The Egyptian Journal of Medical Human Genetics،Vol. 13, no. 3, pp.307-312.
https://search.emarefa.net/detail/BIM-313046
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bashir, Fatimah…[et al.]. Glutathione S-transferase M1 and T1, CYP1A2-2467T delT polymorphisms and non small-cell lung cancer risk in Tunisian sample. The Egyptian Journal of Medical Human Genetics Vol. 13, no. 3 (2012), pp.307-312.
https://search.emarefa.net/detail/BIM-313046
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bashir, Fatimah& Aida, Taieb& Maurice, J. Arnaud& Saguem, Sad. Glutathione S-transferase M1 and T1, CYP1A2-2467T delT polymorphisms and non small-cell lung cancer risk in Tunisian sample. The Egyptian Journal of Medical Human Genetics. 2012. Vol. 13, no. 3, pp.307-312.
https://search.emarefa.net/detail/BIM-313046
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 311-312
رقم السجل
BIM-313046
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر