Protective effect of ginger extract against cisplatin-induced hepatotoxicity and cardiotoxicity in rats

الملخص EN

The protective effect of ginger extract against cisplatin-induced hepatotoxicity and cardiotoxicity was evaluated in 30 albino white rats (weighing 200-300 gm) classified into 5groups (6 rats per each group).

The rats were treated with 0.5g / kg / day or 1g / kg / day ginger extract orally 5 successive days before and 5 successive days after induction of toxicity with intraperitoneal (IP) injection of (10mg / kg ) cisplatin, resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) , total serum billirubin(TSB) , lactate dehydrogenase (LDH) and creatine kinase (CK) enzymes in comparison with the cisplatin treated animals ; ginger extract also improves the histological changes produced by cisplatin in the liver cells and cardiac muscle fiber cells in comparison with the control.

It is concluded that, ginger extract when used concomitantly with cisplatin protects the liver and heart against the toxicity induced by this cytotoxic drug.