The role of anti-cathapsin G among patients with rheumatiod arthritis
المؤلفون المشاركون
Abd al-Majid, Nahla G.
al-Rabbai, Mahmud R.
Abd al-Qadir, Sajid N.
Kamil, Lin K. M.
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 54، العدد 1 (31 مارس/آذار 2012)، ص ص. 68-72، 5ص.
الناشر
تاريخ النشر
2012-03-31
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Perinuclear Antineutrophil Cytoplasmic Autoantibodies (pANCA) have been found in patients with rheumatiod arthritis.
Cathepsin G was the major target antigen.
The present study was to investigate the unknown target antigen of ANCA (Cathapsin G ) in patients with rheumatiod arthritis Objective : This study is to investigate the prevalence of anti-Cathapsin G and rheumatoid factor in Iraqi patients with rheumatiod arthritis.
Patienties & Methods : From1st January until 30 June of 2011 fourty five rheumatiod arthritis patients referred to the immunological department in the teaching laboratory of medical city and twenty five apparently healthy individual used as a control group were investeged to rheumatic factor IgG, IgM, IgA isotypes and anti-Cathapsin G were measured by using enzyme immunoassay technique.
Result : This study showed that the age of patients with rheumatiod arthritis ranged between eigthen years and sixty six years with mean age of (36.08), while the mean level for RF screen, RF IgG, RF IgM, RF IgA isotypes and anti-Cathapsin G were (160.71, 91.7, 136.64, 95.03 and > 9.2 ) respectively.
There were 17(37.8 %) males and 28(62.2 %) females of RA patients.
Immunologically, this study revealed that the serum RF screen was found more than 25 U / ml in all rheumatiod arthritis patients (100 %, P : 0.0001 HS).
On the other hand RF isotypes IgG, RF IgM and IgA level were elevated more than 20 U / ml and it was detected in 31 (68.9 %, P : 0.0001 HS), 31 (68.9 %, P : 0.0001 HS) ,and 32 (71.1 %, P : 0.0001 HS) patients respectively, while the rheumatiod factors (IgG, IgM, and IgA)were normal in healthy control group .
Statistically RF screen has a highly significant association with RF IgG, IgM, and IgA (P = 0.0001).
Anti-Cathapsin G was found in 12(26.7 %, P value : 0.019) of patients with rheumatic arthritis patients.
This study showed a association between the positive result of anti-Cathapsin G with RF IgG and RF IgM (35.5 %, P : 0.047) the results were the same for both, while no association found with RF IgA (25 %, P : 0.692).
Conclusion : A significant correlation was found between anti-Cathapsin G and patients with rheumatiod arthritis and has a significant association with RF IgG and RF IgM while RF IgA had no relation with anti-Cathapsin G.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Rabbai, Mahmud R.& Abd al-Qadir, Sajid N.& Abd al-Majid, Nahla G.& Kamil, Lin K. M.. 2012. The role of anti-cathapsin G among patients with rheumatiod arthritis. Journal of the Faculty of Medicine Baghdad،Vol. 54, no. 1, pp.68-72.
https://search.emarefa.net/detail/BIM-315134
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Rabbai, Mahmud R.…[et al.]. The role of anti-cathapsin G among patients with rheumatiod arthritis. Journal of the Faculty of Medicine Baghdad Vol. 54, no. 1 (2012), pp.68-72.
https://search.emarefa.net/detail/BIM-315134
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Rabbai, Mahmud R.& Abd al-Qadir, Sajid N.& Abd al-Majid, Nahla G.& Kamil, Lin K. M.. The role of anti-cathapsin G among patients with rheumatiod arthritis. Journal of the Faculty of Medicine Baghdad. 2012. Vol. 54, no. 1, pp.68-72.
https://search.emarefa.net/detail/BIM-315134
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 71-72
رقم السجل
BIM-315134
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر