The relationship of adiponctin leptin ratio with metabolic syndrome

الملخص EN

Background : Metabolic syndrome is a cluster of risk factors for atherosclerotic cardiovascular disease caused by abdominal obesity, such as hyperglycemia, hypertension, dyslipidemia, and insulin resistance.

Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acidcatabolism.

Adiponectin is exclusively secreted from adipose tissue into the bloodstream.

Leptin, a hormone synthesized by fat tissue had been noted to regulate energy balance and metabolism.

In this study investigated the relationships of adiponectin / leptin ratio with metabolic syndrome in apparently healthy Iraqi male adults.

Objective : This study was designed to investigate the relationship of adiponectin / leptin ratio with metabolic syndrome in apparently healthy Iraqi male adults.

Methods : Ninety male subjects were enrolled in study (mean age, 40.97 ± 7.94 years).

Serum leptin level and adiponectin level were measured using an enzyme-linked immunosorbent assay.

And the presence of metabolic syndrome was assessed.

Results : Mean leptinlevel was significantly higher (7.29 ± 0.38 ng / ml), whileadiponectin andadiponectin / leptinratio was significantly lower (4.78 ± 0.24 μg / ml ; 0.74 ± 0.07) respectively in subjects with MS.

With increasingnumber of metabolic syndrome components, the mean values of leptinincreased and the adiponectin and adiponectin / leptindecreased.

Conclusion : adiponectin / leptinratio correlated well with the presence and number of metabolic syndrome components in Iraqi male subjects.