Quantitative analysis of IgG antinuclear antibody in chronic periodontitis patients
المؤلفون المشاركون
al-Ghurabei, Batul H.
al-Alusi, Hind Wail
al-Hasan, Ahmad A.
المصدر
Journal of Baghdad College of Dentistry
العدد
المجلد 24، العدد 3 (30 سبتمبر/أيلول 2012)، ص ص. 145-148، 4ص.
الناشر
تاريخ النشر
2012-09-30
دولة النشر
العراق
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Periodontitis is a bacterial infection of tooth-supporting tissues ; the immunopathology mechanisms include inflammatory cells and chemical mediators, which persist inflammation and develop a local autoimmune.
The presence of autoantibodies against extracellular matrix components, anti-neutrophil cytoplasmic antibodies (ANCA) and anti-DNA was detected.
This study aimed to provide evidence of altered humoral immune response in chronic periodontitis, as well as to determine the presence of auto-antibodies in this disease.
Subjects and Methods : blood samples were collected from 35 patients with chronic periodontitis (20 with sever periodontitis and 15 with moderate periodontitis) and from 30 healthy age and sex matched individuals served as controls.
Clinical periodontal parameters used in this study were plaque index, gingival index, probing pocket depth, clinical attachment level and bleeding on probing.
The levels of serum IgG-antinuclear antibody were determined using enzyme-linked immunosorbent assays, whereas serum immunoglobulin (IgG, IgM and IgA) were estimated by single radial immune diffusion method.
Results : serum levels of IgG-antinuclear antibody and IgG were significantly higher in sever chronic periodontitis than in moderate chronic periodontitis and healthy controls (p < 0.05).
On the other hand, the serum levels of IgM and IgA showed no significant differences among three studied groups (p > 0.05).
Concerning the correlation between serum IgG-antinuclear antibody and clinical periodontal parameters, the level of this autoantibody did not show any correlation with clinical parameters of periodontitis (p > 0.05).
Conclusion : the production of antibodies against self-structures could be involved in the pathogenic mechanism of chronic periodontitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Ghurabei, Batul H.& al-Alusi, Hind Wail& al-Hasan, Ahmad A.. 2012. Quantitative analysis of IgG antinuclear antibody in chronic periodontitis patients. Journal of Baghdad College of Dentistry،Vol. 24, no. 3, pp.145-148.
https://search.emarefa.net/detail/BIM-315226
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hasan, Ahmad A.…[et al.]. Quantitative analysis of IgG antinuclear antibody in chronic periodontitis patients. Journal of Baghdad College of Dentistry Vol. 24, no. 3 (2012), pp.145-148.
https://search.emarefa.net/detail/BIM-315226
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Ghurabei, Batul H.& al-Alusi, Hind Wail& al-Hasan, Ahmad A.. Quantitative analysis of IgG antinuclear antibody in chronic periodontitis patients. Journal of Baghdad College of Dentistry. 2012. Vol. 24, no. 3, pp.145-148.
https://search.emarefa.net/detail/BIM-315226
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendices : p. 148
رقم السجل
BIM-315226
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر