Over expression of HER2 neu oncogene in breast cancer in Diwanya city by immunohistochemistry

الملخص EN

This study was conducted to estimate the over expression of HER-2 \ neu protein in human breast carcinoma and to show its possible correlation to the pathological parameters (histological type, grade and age).

We evaluated the available tissue blocks of 49 patients with breast lesions who had collected from private laboratory between January 2007 and October 2009.

All cases were female.

The mean age of the patients was 46.5 years (range, 20 to 73 years old).

38 (77.5 %) cases were of infiltrative ductal carcinoma and 11 (22.5 %) cases were of infiltrative lobular carcinoma The tumors were grade I, II, and III in 3 (7.9 %), 24 (63.2 %), and11 (28.9) cases, Respectively.

From 49 cases, A total of 16 (32.25 %) cases were positive for overexpression of HER-2 / neu oncogene, all the positive cases was with IDC, the intermediate histological grades of the breast IDC were associated with highest expression of HER-2 / neu.

There were 14 cases of HER-2 / neu-positive (58.4 %) with a grade II tumor, 2 (37.5 %) with grade III .There was a significant relation in HER-2 / neu overexpression with the invasive ductal carcinoma and grades of tumor but no correlation was detected between HER-2 / neu overexpression and the patient’s age.

Aim of the Study : This study was conducted to estimate the overexpression of HER- / 2 neu protein in human breast carcinoma and to show its possible correlation to the pathological parameters ( types , grade and age).