Synthesis and antibacterial activity of bis-oxadiazole derivatives

الملخص EN

New compounds containing two heterocyclic rings (1,2,4 and 1,3,4- oxadiazole)in the same molecules have been synthesized through many reactions .

Prepared of 1,2,4-oxadiazole derivatives (3) by refluxing the oxime compound (2) and ethyl p-methyl benzoate with sodium ethoxide for 48 hrs.

Synthesized the 1,3,4- oxadiazole derivatives (7a-l) by reaction prepared hydrazide and many acids with phosphorus oxychloride (POCl3).

All the Synthesized compounds were characterized by melting points, FTIR and 1H-NMR data.

All the final compounds have been screened in vitro for their antibacterial activities against five types of bacteria [Grampositive( S.

aureus, S.

cerevisiae and C.

diphtheria) and the Gram-negative(E.

coli and P.

aeruginosa)] in two concentration (100 and 200 )μg/mL.

The result showed considerable antibacterial activities against Gram-positive (G+) , but did not show any antibacterial activities against Gram-negative (G-).