![](/images/graphics-bg.png)
Analgesic effect of melatonin in mice
المؤلف
المصدر
al-Kindy College Medical Journal
العدد
المجلد 8، العدد 2 (31 ديسمبر/كانون الأول 2012)، ص ص. 28-31، 4ص.
الناشر
تاريخ النشر
2012-12-31
دولة النشر
العراق
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background : Melatonin is the main hormone secreted by the pineal gland.
This indole compound (N-acetyl-5-methoxytryptamine) is derived from serotonin after two biochemical steps.
Melatonin has been implicated in some pharmacological effects including sedative / hypnotic, anticonvulsant activity and others.
The aim of this study was to investigate the antinociceptive effect of different doses of melatonin administered i.p.
to mice, and then, to find the dose- response line of melatonin in mice as analgesic agent.
Methods : The dose response effect of melatonin (10, 50, and 100mg / kg) were assessed against control using tail flick test in mice as a model of nociceptive pain.
In this model, all doses of melatonin were given intraperitoneally 15 min before immersion of tail in hot water 50°C, and Tail Flick Latency was measured before, and after (15, 30, 60 and 120 min) administration of melatonin.
Results : Administration of melatonin i.p.
to mice significantly P ≤ 0.05 increase tail flick latency in melatonin treated groups after 30 min and 60 min compared to baseline values ; while after 120 min, administration of melatonin produce significant and dose dependent antinociceptive effect following its i.p.
administration.
The percentage increase in tail flick latency produced by i.p.
administration of melatonin doses of 10, 50, and 100 mg / kg were 86.59 %, 156.05 % and 169.19 % respectively when compared to baseline values.
Conclusions : The present study showed that melatonin produces analgesic effect in a dose dependent manner in mice, further studies are required to know the exact mechanism by which melatonin exerts this analgesic effect.
Keywords : melatonin, analgesia, pain
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Imad Hashim. 2012. Analgesic effect of melatonin in mice. al-Kindy College Medical Journal،Vol. 8, no. 2, pp.28-31.
https://search.emarefa.net/detail/BIM-316826
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Imad Hashim. Analgesic effect of melatonin in mice. al-Kindy College Medical Journal Vol. 8, no. 2 (2012), pp.28-31.
https://search.emarefa.net/detail/BIM-316826
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Imad Hashim. Analgesic effect of melatonin in mice. al-Kindy College Medical Journal. 2012. Vol. 8, no. 2, pp.28-31.
https://search.emarefa.net/detail/BIM-316826
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 30-31
رقم السجل
BIM-316826
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)