Evaluate the effect of different doses for grape seed extract in mice

الملخص EN

The aim of this study was to evaluate the effect of different doses for grape seeds extract in internal organs of mice.

Histopathological, cytogentical and haematological studies were done to evaluate this effect.

The study was done on (24) mice divided into four groups (6 / group) for one month.

Group one treated with PBS considered as control Negative, Group two treated with (100mg / kg B.W.) of grape seed extract, Group three treated with (200mg / kg B.W.) of grape seed extract, Group four treated with (300mg / kg B.W.) of grape seed extract.

The results showed that (200, 300mg / kg B.W.) cause significant decrease in hematological, cytogentical parameters and severe histopathological changes while at dose (100mg / kg B.W.) induce immune pathological response organ with amelioration of haematological and cytogentical parameters.

In conclusion the effect of grape seed extract was dose dependent that more severe toxicopathological changes appeared in haemtological, cytogentical and histopathological results at doses (200 and 300mg / kg B.W.) while at dose ( 100mg / kg B.W.) induce immunopathological response internal organs with amelioration of haematological and cytogentical parameters.