Ghrelin level is associated with other biochemical parameters in obese diabetic patients
المؤلفون المشاركون
al-Hakim, Husayn Kazim Abd al-Husayn
Ali, Muntazar Muhammad
المصدر
al-Kufa University Journal for Biology
العدد
المجلد 4، العدد 2 (31 ديسمبر/كانون الأول 2012)12ص.
الناشر
جامعة الكوفة كلية العلوم قسم علوم الحياة
تاريخ النشر
2012-12-31
دولة النشر
العراق
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Aims : When T2DM associated with obesity they form a very harmful combination that exacerbates the consequences of each other leading to various disorders.
The present study aims to assess the ghrelin hormone level in obese diabetic patients and to find out a possible relationship between ghrelin level with different parameters including lipid profile, glycated hemoglobin (HbA1c), insulin resistance (IR) parameters calculated from Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), HOMA insulin sensitivity (HOMA2- % S), and HOMA beta cells function (HOMA2- % B). Methods : Sixty obese T2DM patients with were participated in the study.
Lipid profile parameters and blood sugar were measured spectrophotometrically.
Ghrelin and insulin measurements were carried out using ELISA technique.
HbA1c were measured by ion-exchange chromatography.
Insulin resistance parameters were calculated using HOMA2-Calculator software Results : The results showed that obese diabetic patients have a poor glycemic control and more than half of obese diabetic patients were insulin resistant (IR) according to (HOMA2- IR ≥ 3).
Typical dyslipidemia are present in obese diabetic patients indicating higher risk factor for cardiovascular diseases.
Mean ghrelin level is low in diabetic obese patients and non-IR patients have moderately higher ghrelin level than IR patients.
Insulin sensitivity (HOMA2- % S) and beta-cell function (HOMA2- % B) indicators are lower in diabetic patients than control group. In obese diabetic patients, ghrelin level is negatively correlated with BMI, cholesterol, HbA1c, atherogenic ratios, and HOMA2- % S.
Ghrelin level is positively correlated with HDL-C and HOMA2-IR. Conclusions : Low ghrelin level is associated with poor diabetes control and bad prognosis parameters in obese diabetic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hakim, Husayn Kazim Abd al-Husayn& Ali, Muntazar Muhammad. 2012. Ghrelin level is associated with other biochemical parameters in obese diabetic patients. al-Kufa University Journal for Biology،Vol. 4, no. 2.
https://search.emarefa.net/detail/BIM-318905
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hakim, Husayn Kazim Abd al-Husayn& Ali, Muntazar Muhammad. Ghrelin level is associated with other biochemical parameters in obese diabetic patients. al-Kufa University Journal for Biology Vol. 4, no. 2 (2012).
https://search.emarefa.net/detail/BIM-318905
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hakim, Husayn Kazim Abd al-Husayn& Ali, Muntazar Muhammad. Ghrelin level is associated with other biochemical parameters in obese diabetic patients. al-Kufa University Journal for Biology. 2012. Vol. 4, no. 2.
https://search.emarefa.net/detail/BIM-318905
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendix
رقم السجل
BIM-318905
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر