Hormonal profile in intracytoplasmic sperm injection cycles may predict poor responders : a comparative study

الملخص EN

Background : ovarian response varies considerably among individuals and depends on various fators.

Poor response in In Vitro Fertilization (IVF) yields lesser oocytes and is associated with poorer pregnancy perspective.

Cycle cancellation due to poor response is frustrating for both clinicians and the patient.

Objective: This paper studies some ovarian reserve hormonal profiles which may be a contributing factor for poor ovarian response in Intra Cytoplasmic Injection (ICSI) cycles.

Design : A prospective controlled trial.

Setting : fertility unit in Al-Sadar medical city, Najaf province.

Subjects and Methods : eighteen poor responders to controlled ovarian hyper stimulation with gonadotropin have been withdrawn from 67 initially selected participants intended to undergo intracytoplasmic sperm injection as a treatment option for their infertility.

Basal cycle day 2 hormonal levels for follicular stimulating hormone (FSH), Anti mullerian hormone (AMH) and estradiol(E2) as well as antral follicular count (AFC) were measured and compared for both groups.

Results : the poor responder group found to be of higher age and basal serum FSH and lower basal serum AMH.

Conclusions : some markers of ovarian reserve may be used as a predictor of poor responders in assisted reproduction programme.