The possible protective effect of green tea extract against methotrexate-induced liver injury in male rats

الملخص EN

This study was performed to evaluate the influence of simultaneous administration of aqueous green tea extract (1.5 %) with methotrexate (0.5 mg / kg) on the status of glutathione (GSH) in liver tissue, with measuring the activity of serum liver enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST)] and serum bilirubin levels.

Administrations of aqueous green tea extract alone resulted in a significant increase in liver tissue GSH level and when it was used with MTX it ameliorated MTX-induced changes in level of this parameter.

Regarding enzymes activities, administration of aqueous green tea extract resulted in an alleviating effect on MTX-induced elevation in serum ALT activity with a non-significant reduction in serum AST activity; it also significantly reduced MTX-induced elevation in total serum bilirubin level, these effects may be related to direct or indirect antioxidant property of green tea extract.